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- Table of Contents
, No Gclids
Galectin-9 Antibodies
AND LGALS9 ELISA kits, Galectin-9 Proteins
Many biological assays use antibodies to detect Galectin-9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Galectin-9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Galectin-9 antibodies...
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LGALS9 Infographic by Boster Bio
All LGALS9 Products
Product
Figures
Specificity
Applications
Price
Human Galectin-9 / Gal 9 ELISA Kit PicoKine®
1 Citations 13 Q&As
Human
ELISA
$499
Cat # EK1113
96 wells/kit, with removable strips.
Cat # EK1113
96 wells/kit, with removable strips.
Human
IHC, WB
$523
Cat # M03415
100 µl
Cat # M03415
100 µl
LGALS9 Overview
Facts about Galectin-9.
Galectin-9 (LGALS9)
Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920).
Also stimulates bactericidal activity in infected macrophages by inducing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, raising disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and improving cell regeneration (PubMed:21670307).
Gene Information
| Human | |
|---|---|
| Gene Name: | LGALS9 |
| Uniprot: | O00182 |
| Entrez: | 3965 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Ecalectin; GAL9; gal-9; galectin 9; Galectin9; Galectin-9; HUAT; lectin, galactoside-binding, soluble, 9; LGALS9; LGALS9A; MGC117375; MGC125973; MGC125974; Tumor antigen HOM-HD-21; urate transporter/channel protein
Molecular Weight
Mass (kDA):
39.518 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q11.2 |
| Sequence: | 17; NC_000017.11 (27631172..27649560) |
Tissue Specificity
Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).
Subcellular Localizations
Cytoplasm. Nucleus. Secreted. May also be secreted by a non-classical secretory pathway (By similarity). Secreted by mesenchymal stromal cells upon IFNG stimulation (PubMed:23817958).; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
Diseases
- Tissue Adhesions
- Inflammation
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Melanoma
- Autoimmune Reaction
- Asthma
- Infective Disorder
- Autoimmune Diseases
- Endometrial Polyp
- Eosinophilia
- Virus Diseases
Pathways
- Pathogenesis
- Cell Adhesion
- Transport
- Cell Death
- Urate Transport
- Cell Proliferation
- Secretion
- Immune Response
- Chemotaxis
- Induction Of Apoptosis
- Localization
- Cell Differentiation
- Excretion
PTMs
- Phosphorylation
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LGALS9
bosterbio.com/bosterbio-gene-info-cards/LGALS9
References
PMID: 9045665 by Tuereci O., et al. Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease.
PMID: 9642261 by Matsumoto R., et al. Human ecalectin, a variant of human galectin-9, is a novel eosinophil chemoattractant produced by T lymphocytes.
2 Publications of Boster Galectin-9 Antibodies & ELISA Kits
- PubMed ID: 10.3389/fimmu.2018.01648, Galectin-3 and Galectin-9 May Differently Regulate the Expressions of Microglial...
- PubMed ID: 10.1155/2020/2583257, Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients wit...
*More publications can be found for each product on its corresponding product page