LDLRAD4 Antibodies

AND LDLRAD4 ELISA kits, LDLRAD4 Proteins

Many biological assays use antibodies to detect LDLRAD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LDLRAD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LDLRAD4 antibodies...

We validate the specificity of these antibodies to LDLRAD4 by testing them on tissues known to express LDLRAD4 positively and negatively. Browse below to find the LDLRAD4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LDLRAD4 Infographic by Boster Bio

All LDLRAD4 Products

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Specificity

Applications

Price

C18orf1 (LDLRAD4) (NM_181483) Human Recombinant Protein

$813
Cat # PROTO15165
20 µg

C18orf1 (LDLRAD4) (NM_181483) Human Over-expression Lysate

Human

$628
Cat # LS000753
100 µg

LDLRAD4 Overview

Facts about Low-density lipoprotein receptor class A domain-containing protein 4.

LDLRAD4 3D structure. Source: alphafold

Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)

Functions as a negative regulator of TGF-beta signaling and thereby likely plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 into the TGF-beta receptor.

Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates into the nucleus to regulate transcription. Through discussion with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and protect against propagation of the intracellular signal.

Gene Information

Human
Gene Name:	LDLRAD4
Uniprot:	O15165
Entrez:	753

Family

Belongs to:

PMEPA1 family

Alternative Names

C18orf1; chromosome 18 open reading frame 1; clone 22; hypothetical protein LOC753

Molecular Weight

Mass (kDA):
33.9 kDA

Genomic Context


Human

Location:	18p11.21
Sequence:	18; NC_000018.10 (13217606..13652754)

Tissue Specificity

Expressed in lymphocytes.

Subcellular Localizations

Early endosome membrane; Single-pass membrane protein.

PTMs

Disulfide bond

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LDLRAD4

References

PMID: 9479497 by Yoshikawa T., et al. Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2.

PMID: 19461657 by Meerabux J.M., et al. Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia.