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Plastin-2 Antibodies
AND LCP1 ELISA kits, Plastin-2 Proteins
Many biological assays use antibodies to detect Plastin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Plastin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Plastin-2 antibodies...
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LCP1 Infographic by Boster Bio
All LCP1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03361
100 μg/vial
Cat # A03361
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M03361-1
100 μl/vial
Cat # M03361-1
100 μl/vial
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03361-2
100 μl/vial
Cat # M03361-2
100 μl/vial
LCP1 Overview
Facts about Plastin-2.
Plastin-2 (LCP1)
Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403).
Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). .
Gene Information
| Human | |
|---|---|
| Gene Name: | LCP1 |
| Uniprot: | P13796 |
| Entrez: | 3936 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CP64; DKFZp781A23186; FLJ25423; FLJ26114; FLJ39956; LC64PPLS2bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin)); LCP-1; LPL; L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P); L-PLASTIN; lymphocyte cytosolic protein 1 (L-plastin); Lymphocyte cytosolic protein 1; Lymphocyte cytosolic protein-1 (plasmin); plastin 2; plastin-2
Molecular Weight
Mass (kDA):
70.288 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q14.13 |
| Sequence: | 13; NC_000013.11 (46125923..46182177, complement) |
Tissue Specificity
Detected in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia, in spleen and other lymph node-containing organs. Expressed in peripheral blood T- lymphocytes, neutrophils, monocytes, B-lymphocytes, and myeloid cells.
Subcellular Localizations
Cytoplasm, cytoskeleton. Cell junction. Cell projection. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Associated with the actin cytoskeleton at membrane ruffles. Relocalizes to actin-rich cell projections upon serine phosphorylation (PubMed:16636079).
Diseases
- Malignant Neoplasms
- Neoplasms
- Tissue Adhesions
- Inflammation
- Cell Invasion
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Malignant Neoplasm Of Lung
- Infective Disorder
- Retinoblastoma
- Leukemia
- Essential Hypertension
Pathways
- Localization
- Cell Activation
- Cell Motility
- Macrophage Activation
- Protein Phosphorylation
- Cell Migration
- T Cell Activation
- Dosage Compensation
- Cell Proliferation
- Cell Development
- Larval Development
- Bone Resorption
- Transport
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LCP1
bosterbio.com/bosterbio-gene-info-cards/LCP1
References
PMID: 2252891 by Zu Y., et al. 65-kilodalton protein phosphorylated by interleukin 2 stimulation bears two putative actin-binding sites and two calcium-binding sites.
PMID: 3211125 by Lin C.-S., et al. Molecular cloning and characterization of plastin, a human leukocyte protein expressed in transformed human fibroblasts.