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- Table of Contents
Facts about Phosphatidylcholine-sterol acyltransferase.
Has a taste for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and affects cerebral spinal fluid (CSF) APOE- and APOA1 levels.
Human | |
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Gene Name: | LCAT |
Uniprot: | P04180 |
Entrez: | 3931 |
Belongs to: |
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AB hydrolase superfamily |
EC 2.3.1.43; lecithin-cholesterol acyltransferasePhospholipid-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase
Mass (kDA):
49.578 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (67939750..67944120, complement) |
Detected in blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Detected in cerebral spinal fluid (at protein level) (PubMed:10222237). Detected in liver (PubMed:3797244, PubMed:3458198). Expressed mainly in brain, liver and testes.
Secreted. Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
PMID: 3797244 by McLean J., et al. Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.
PMID: 3458198 by McLean J., et al. Cloning and expression of human lecithin-cholesterol acyltransferase cDNA.