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- Table of Contents
Facts about Phosphatidylcholine-sterol acyltransferase.
Has a taste for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE- containing lipoproteins secreted from glia and affects cerebral spinal fluid (CSF) APOE- and APOA1 levels.
Human | |
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Gene Name: | LCAT |
Uniprot: | P04180 |
Entrez: | 3931 |
Belongs to: |
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AB hydrolase superfamily |
EC 2.3.1.43; lecithin-cholesterol acyltransferasePhospholipid-cholesterol acyltransferase; phosphatidylcholine-sterol acyltransferase
Mass (kDA):
49.578 kDA
Human | |
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Location: | 16q22.1 |
Sequence: | 16; NC_000016.10 (67939750..67944120, complement) |
Detected in blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Detected in cerebral spinal fluid (at protein level) (PubMed:10222237). Detected in liver (PubMed:3797244, PubMed:3458198). Expressed mainly in brain, liver and testes.
Secreted. Secreted into blood plasma (PubMed:3458198, PubMed:8820107, PubMed:10222237). Produced in astrocytes and secreted into cerebral spinal fluid (CSF).
You have come to the right spot if you are looking for an LCAT mark. Boster Bio has a great selection of single-pass membrane proteins, including the CD2 marker and the SAA1 antigen. The Boster Bio CD2 marker is a single-pass membrane protein and provides guides for optimization. This article outlines the best uses of the Boster Bio CD2 marker.
The SAA1 gene encodes a protein that binds with adrenergic receptors. This protein plays a crucial role in pregnancy. In addition to its role in fetal development and placental trophoblast invasion, SAA1 also induces the expression of inflammatory factors in the human body, including HMGB1 and IL-1. Boster Bio's SAA1 markers showed an increase in SAA1 levels during spontaneous labor. This was without infection. Cell aging and high mobility group boxes are thought to trigger sterile swelling. Serum Amyloid A1 may be directly or indirectly involved. It may also trigger the release of IL-1 in macrophages and HMGB1 within macrophages. This may contribute to the inflammatory reactions.
SAA is a biomarker that is highly sensitive for AA Amyloidosis. However, it may not always be 100% sensitive. Its concentrations can vary, so it may be difficult to diagnose a clinical condition. SAA1 is highly specific and researchers use it to screen patients for serious infections. The SAA1/SAA2 ratio showed a very high sensitivity/specificity ratio, which means it could be useful for early detection and diagnosis of serious diseases.
The SAA1 proteins interact with the outer cell protein A of Gram negative bacteria, promoting their uptake and use by neutrophils. SAA1 interacts directly with retinol. This results in a reduction of the bacterial burden. SAA1 knockout mice had impaired Th27 responses in gut epithelial cell lines, which suggests that the gene is involved with the regulation of immunity. Multiple studies have shown that the SAA1 protein is a key regulator for immune response.
The Boster Bio IL6 marker is an in vitro diagnostic test that measures IL-6 levels in patients with septic shock and severe sepsis. The marker has the same diagnostic value as the IL-6 level, but it has a much shorter half-life and a narrow detection window, making it limited for monitoring drug treatment and the host response to the medication. Steven Xia created the Boster Bio IL6 indicator and it has been approved by a variety of organizations. In fact, more that 29,000 publications have cited the antibodies of Boster Bio.
The IL-6 cytokine group plays a crucial role in the initiation, progression, and maintenance of many chronic diseases such as cancer. They are also used in cancer diagnosis and prognosis, and have been identified in various fluids, including saliva, serum, and bronchoalveolar lavage fluid. IL-6 serves many functions in our bodies, including the repair, maintenance, and protection against oxidative damage, as well as proliferation, invasion, or metastasis.
Using IL6 as a cancer diagnostic can help identify patients who are more likely to respond to treatments. The IL6 indicator can also be used for determining if chemotherapy is effective in the treatment or not. Researchers are also working on finding novel regulatory targets for the IL-6 family of cytokines to develop effective cancer therapies. Many patients will find the Boster bio IL6 marker useful.
The IL-6 marker produced very high NPV and PPV values, which are high when compared to other IL-6 biomarkers. IL-6's NPV measured 97.3 percent for PRs between five and 10, and 95.7% in PRs between five and fifteen. These high values indicate that Boster Bio’s IL6 indicator has great potential for prognosis.
The CD2 mark is a membrane protein that acts as a single-pass receptor and interacts with the lymphocyte-associated antigens CD58 (and BCM1 (lymphocyte function-associated antigens CD58)). The CD2 is an integral component of the immune systems and aids in targeting pathogens. It activates killer T cells (also known as CD8 T cell) in the immune system. This marker allows scientists to determine whether a person is infected and the strength their immune system.
CD2 interacts with adhesion molecules in the body. It is present on the surface T cells, human NK cells and most T lymphomas. It is also known as lymphocyte function–associated antigen-3 or LFA-2 receptor. It is often used as a specific marker for T cells, which helps differentiate them from B cell neoplasms and T cell lymphomas.
The immune system is dominated by the single-pass transmembrane receiver, human prolactin and LCAT. Although prolactin is most well-known for its role during lactation, it also plays important roles in metabolism as well as osmoregulation. It activates multiple signal transmission pathways, including Jak/Stat/PI3K/Akt. These proteins have both proliferative as well as anti-apoptotic properties.
Low levels of human prolactin may be a sign of hypopituitarism, a condition in which the pituitary gland does not function at full speed. While a low prolactin level does not necessarily require medical treatment, low levels may signal a more serious problem, such as a prolactinoma. The exact diagnosis will determine what treatment is required. Treatment will be minimal if the prolactinoma size is small. For other cases, medication might be necessary.
A prolactin testing measures the level prolactin levels in a person's blood. This hormone is made in the pituitary, located just below the brain. While prolactin levels rise in women during pregnancy due to the development of breastmilk, high levels may also be found in men. The body's ability eliminate prolactin might be affected if there is kidney disease or liver failure. Polycysticovarian syndrome and other conditions can increase prolactin in the blood.
Although human LCAT expression is correlated with breast cancer, the correlation between human LCAT expression and aggressiveness remains unclear. There is still much to be done before we can fully understand the relationship between plasma LCAT levels (and breast cancer) and their correlation. Although the results are not conclusive, this study provides a better understanding of the lipoproteins pathway. It is important for you to know that the LCAT mark can be detected in a variety of types of breast-cancer.
CD8a is an antigen on the cell surface that is involved in efficient cell-cell interaction. It maps to gene 2p11.2 as a coreceptor that recognizes antigens from class I MHC molecules, APC, and class I MHC proteins. It is a glycoprotein that has two alpha chains (one beta) and significant homology to immunoglobulin's variable light chain.
PMID: 3797244 by McLean J., et al. Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression.
PMID: 3458198 by McLean J., et al. Cloning and expression of human lecithin-cholesterol acyltransferase cDNA.