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, No Gclids
LAT2 Antibodies
AND LAT2 ELISA kits, LAT2 Proteins
Many biological assays use antibodies to detect LAT2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with LAT2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop LAT2 antibodies...
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LAT2 Infographic by Boster Bio
All LAT2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IP, ICC, WB
$330
Cat # M02496-1
0.1 mg
Cat # M02496-1
0.1 mg
LAT2 Overview
Facts about Linker for activation of T-cells family member 2.
Linker for activation of T-cells family member 2 (LAT2)
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.
Couples stimulation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. .
Gene Information
| Human | |
|---|---|
| Gene Name: | LAT2 |
| Uniprot: | Q9GZY6 |
| Entrez: | 7462 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
LAB; LABWilliams-Beuren syndrome chromosomal region 15 protein; Linker for activation of B-cells; linker for activation of T cells family, member 2; linker for activation of T-cells family member 2; Membrane-associated adapter molecule; Non-T-cell activation linker; NTAL; NTALWilliams-Beuren syndrome chromosomal region 5 protein; WBS15; WBSCR15; WBSCR5; WBSCR5HSPC046; Williams-Beuren syndrome chromosome region 5; WSCR5
Molecular Weight
Mass (kDA):
26.55 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q11.23 |
| Sequence: | 7; NC_000007.14 (74210006..74229834) |
Tissue Specificity
Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B- cells, NK cells and monocytes. Absent from T-cells (at protein level).
Subcellular Localizations
Cell membrane; Single-pass type III membrane protein. Present in lipid rafts.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Leukemia
- Hypertensive Disease
- Malignant Squamous Cell Neoplasm
- Liver Carcinoma
- Tissue Adhesions
- Multiple Myeloma
- Eye Infections
- Autoimmunity
Pathways
- Transport
- Amino Acid Transport
- Cell Activation
- Localization
- Cell Proliferation
- Cell Growth
- Reverse Transcription
- Arginine Transport
- Pathogenesis
- Lymphocyte Activation
- T Cell Activation
- Mast Cell Activation
- Gene Silencing
PTMs
- Phosphorylation
- Carboxylation
- Palmitoylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LAT2
bosterbio.com/bosterbio-gene-info-cards/LAT2
References
PMID: 11124535 by Doyle J.L., et al. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome.
PMID: 11003705 by Martindale D.W., et al. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23.