La-related protein 1 Antibodies

AND LARP1 ELISA kits, La-related protein 1 Proteins

Many biological assays use antibodies to detect La-related protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with La-related protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop La-related protein 1 antibodies...

We validate the specificity of these antibodies to La-related protein 1 by testing them on tissues known to express LARP1 positively and negatively. Browse below to find the LARP1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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LARP1 Infographic by Boster Bio

All LARP1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human

$405
Cat # A04488
100ul

Human, Mouse

ELISA, WB

$380
Cat # A04488-1
100ul

Anti-LARP1 Mouse Monoclonal Antibody [Clone ID: OTI4E2]

Human, Mouse, Rat

$523
Cat # M04488
100 µl

Anti-LARP1 Antibody Picoband®

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A04488-2
100 μg/vial

LARP1 Overview

Facts about La-related protein 1.

LARP1 3D structure. Source: alphafold

La-related protein 1 (LARP1)

RNA-binding protein that promotes translation of certain classes of mRNAs downstream of the mTORC1 complex (PubMed:24532714, PubMed:25940091). Associates with the mRNA 5'cap in an MTOR-dependent manner and associates with mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding for ribosomal proteins and lots of components of the translation machinery (PubMed:24532714, PubMed:25940091, PubMed:26206669).

Associates with actively translating ribosomes via interaction with PABPC1/PABP and stimulates translation of mRNAs containing a 5'TOP, thereby regulating cell growth and proliferation (PubMed:20430826, PubMed:25940091). Positively regulates the replication of dengue virus (DENV) (PubMed:26735137).

Gene Information

Human
Gene Name:	LARP1
Uniprot:	Q6PKG0
Entrez:	23367

Family

Belongs to:

LARP family

Alternative Names

KIAA0731LARPMGC19556; La ribonucleoprotein domain family member 1; La ribonucleoprotein domain family, member 1; la-related protein 1

Molecular Weight

Mass (kDA):
123.51 kDA

Genomic Context


Human

Location:	5q33.2
Sequence:	5; NC_000005.10 (154682979..154817605)

Subcellular Localizations

Cytoplasm. Cytoplasmic granule. Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.

Diseases

Malignant Neoplasms
Neoplasms
Mammary Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Malignant Neoplasm Of Breast

Interacting Proteins

CCDC155

Pathways

Translation
Transport
Cell Division
Vesicle Transport
Cell Migration
Cell Proliferation
Head Involution

Oogenesis
Spermatogenesis

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/LARP1

References

PMID: 17693683 by Tang L.-Y., et al. Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PMID: 20430826 by Burrows C., et al. The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration.