This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
L1CAM Antibodies
AND L1CAM ELISA kits, L1CAM Proteins
Many biological assays use antibodies to detect L1CAM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with L1CAM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop L1CAM antibodies...
Previous: CBLIF
Next: LAD1
L1CAM Infographic by Boster Bio
All L1CAM Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00729S1181
100ul
Cat # A00729S1181
100ul
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, WB
$523
Cat # M00729-1
100 µl
Cat # M00729-1
100 µl
L1CAM Overview
Facts about Neural cell adhesion molecule L1.
Neural cell adhesion molecule L1 (L1CAM)
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the creation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in numerous processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis.
In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | L1CAM |
| Uniprot: | P32004 |
| Entrez: | 3897 |
Family
| Belongs to: |
|---|
| immunoglobulin superfamily |
Alternative Names
antigen identified by monoclonal R1; CAML1; CAML1N-CAML1; CD171 antigen; CD171; HSAS; HSAS1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM-L1; NCAM-L1; neural cell adhesion molecule L1; S10; SPG1
Molecular Weight
Mass (kDA):
140.003 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq28 |
| Sequence: | X; NC_000023.11 (153861514..153886173, complement) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, growth cone. Cell projection, axon. Cell projection, dendrite. Colocalized with SHTN1 in close apposition with actin filaments in filopodia and lamellipodia of axonalne growth cones of hippocampal neurons (By similarity). In neurons, detected predominantly in axons and cell body, weak localization to dendrites (PubMed:20621658).
Diseases
- Tissue Adhesions
- Hydrocephalus
- Neoplasms
- Malignant Neoplasms
- X-linked Hydrocephalus Syndrome
- Paraplegia
- Nervousness
- Spastic Paraplegia
- Neoplasm Metastasis
- Carcinoma
- Congenital Absence
- Malignant Paraganglionic Neoplasm
Pathways
- Cell Adhesion
- Cell Migration
- Cell Proliferation
- Pathogenesis
- System Development
- Localization
- Nervous System Development
- Axon Guidance
- Proteolysis
- Cell Motility
- Angiogenesis
- Rna Interference
- Brain Development
PTMs
- Phosphorylation
- Cleavage
- Methylation
- Glycosylation
Research Areas
- Cellular Markers
- Glia Markers
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/L1CAM
bosterbio.com/bosterbio-gene-info-cards/L1CAM
References
PMID: 1932117 by Kobayashi M., et al. Molecular cloning of cell adhesion molecule L1 from human nervous tissue: a comparison of the primary sequences of L1 molecules of different origin.
PMID: 1769655 by Hlavin M.L., et al. Molecular structure and functional testing of human L1CAM: an interspecies comparison.