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- Table of Contents
Facts about Kinase suppressor of Ras 1.
Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity alone.
Human | |
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Gene Name: | KSR1 |
Uniprot: | Q8IVT5 |
Entrez: | 8844 |
Belongs to: |
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protein kinase superfamily |
kinase suppressor of ras 1; kinase suppressor of ras; KSRRSU2
Mass (kDA):
102.16 kDA
Human | |
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Location: | 17q11.2 |
Sequence: | 17; NC_000017.11 (27456441..27626438) |
Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane. In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
PMID: 8521512 by Therrien M., et al. KSR, a novel protein kinase required for RAS signal transduction.
PMID: 10409742 by Stewart S., et al. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.