KRT5 Antibodies

Keratin, type II cytoskeletal 5 (KRT5)

Gene Information

Human
Gene Name:	KRT5
Uniprot:	P13647
Entrez:	3852

Family

Belongs to:
intermediate filament family

Alternative Names

58 kDa cytokeratin; CK5; CK-5; cytokeratin-5; DDD; EBS2; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; K5; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockaynetypes); keratin 5; keratin, type II cytoskeletal 5; Keratin-5; KRT5A; Type-II keratin Kb5

Molecular Weight

Mass (kDA):
62.378 kDA

Genomic Context

Human
Location:	12q13.13
Sequence:	12; NC_000012.12 (52514575..52520394, complement)

Diseases

• Epidermolysis Bullosa
• Neoplasms
• Carcinoma
• Bulla
• Malignant Neoplasms
• Mammary Neoplasms
• Malignant Neoplasm Of Breast
• Dermatologic Disorders
• Malignant Squamous Cell Neoplasm
• Malignant Paraganglionic Neoplasm
• Adenocarcinoma

• Lung Neoplasms
• Neoplasm Metastasis
• Reticulate Acropigmentation Of Kitamura
• Hyperplasia
• Hyperpigmentation
• Skin Diseases, Genetic

Interacting Proteins

• ALOX12
• KIFC3
• KRT14
• KRT15
• KRT31

• KRT38
• KRT40

Pathways

• Pigmentation
• Cell Differentiation
• Cytolysis
• Pathogenesis
• Cell Adhesion
• Localization
• Cell Proliferation
• Transport
• Keratinization
• Immune Response
• Metaphase
• Regeneration
• Cell Growth

• Lung Development
• Hypersensitivity
• Palate Development
• Keratinocyte Differentiation
• Response To Heat
• Eye Morphogenesis
• Tissue Development

PTMs

• Phosphorylation

Research Areas

• Cell Biology
• Cellular Markers

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KRT5

Boster Bio - Best Uses Of The KRT5 Marker

This article will discuss the many advantages of Boster Bio. We will talk about the quality of its products and its validation. This information is pertinent to all scientists around the globe. We will also talk about the numerous applications of the KRT5 Marker. The Boster Bio website offers a variety of useful tools for scientists working in the field. Before making your final decision, however it is important to go through the following sections.

Boster Bio

Boster Bio offers a variety of ELISA kits and research antibodies that can detect KRT5, a biomarker in diverse fields, including neuroscience, cancer inflammation, the field of developmental biology. This antibody is able to bind KRT5 and reacts with mouse and human Keratinocytes. Its sensitivity ranges between 0.1 to 5 picograms. Boster Bio also offers ELISA kits that are able to be used for other purposes.

Products

Researchers have looked for mutations in KRT5 genes to identify an association between KRT5 mutation and basal cell carcinoma susceptibility. A report published in the British Medical Journal BCC4 (613061) reported a link between the KRT5 marker and basal cell carcinoma. A numbering system was also suggested by the authors, based on the location of methionine within the gene.

The KRT5 gene provides instructions for the creation of the keratin-5 protein, which is a fibrous structure that holds the epidermis to the underlying layers of the skin. It is composed of seven amino acids and a central core alpha-helical region. The N and C termini, that contain Glyglyx motif, are serine-rich.

The KRT5 gene is a heterozygous gene that has T-to C transitions in the first half of the sequence. This results in a substitution of alanine in the L12 linker domain. The L12 position is conserved in all type II keratins and contributes to the integrity of filaments. In contrast, alanine in this region reduces the beta-sheet's hydrophobicity and decreases its nature.

Quality

Boster Bio, a leader in picogram-sensitive ELISA kit manufacturing and IHC-optimized monoclonal antibody offers a highly specific antibody against KRT5 from their product line. Boster Bio's antibodies are validated quantitatively against known amounts of recombinant proteins as well as tissues. The products of Boster Bio are suitable for IHC, WB, and Flow analysis.

Validation

Boster Bio has a line of antibodies and ELISA kits for the detection of the KRT5 marker. These antibodies have been approved for use in IHC or WB as well as Flow applications. They have been tested against over 250 tissues. Boster Bio antibodies are designed to react with known amounts of recombinant proteins . They also have a high affinity for their targets. These antibodies are available to purchase directly from Boster Bio and can be used for all types of research.

Cost

Researchers from the field of molecular biology have observed that the expression of the KRT5 gene is highly associated with the presence of the SCGB1A11 gene on tumor cells. The study used single cells from human small airway epithelium , and conducted a principal component analysis (PCGA) on them. The single-cell gradients were analyzed using the TPM (transcripts/million) values of the marker gene markers. Statistics demonstrated statistical significance for the expression levels of SCGB1A1 and KRT5 genes.