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- Table of Contents
13 Citations 15 Q&As
6 Citations 16 Q&As
2 Citations 16 Q&As
5 Citations 4 Q&As
1 Citations 15 Q&As
1 Citations 15 Q&As
Facts about Keratin, type I cytoskeletal 19.
Involved in the Business of myofibers.
Together with KRT8, helps to connect the contractile apparatus to dystrophin at the costameres of striated muscle..
Human | |
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Gene Name: | KRT19 |
Uniprot: | P08727 |
Entrez: | 3880 |
Belongs to: |
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intermediate filament family |
40-kDa keratin intermediate filament; CK19; CK-19; Cytokeratin 19; EndoC; K19; K1CS; keratin 19; keratin, type I cytoskeletal 19; keratin, type I, 40-kd; keratin-19; Krt19; MGC15366
Mass (kDA):
44.106 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (41523617..41528308, complement) |
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
PMID: 2447559 by Stasiak P.C., et al. Sequence of cDNA coding for human keratin 19.
PMID: 2468493 by Bader B.L., et al. Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene.
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