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- Table of Contents
9 Citations 17 Q&As
15 Citations 16 Q&As
7 Citations 15 Q&As
3 Citations 16 Q&As
6 Citations 17 Q&As
3 Citations 16 Q&As
Facts about Keratin, type I cytoskeletal 18.
Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Human | |
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Gene Name: | KRT18 |
Uniprot: | P05783 |
Entrez: | 3875 |
Belongs to: |
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intermediate filament family |
Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-18; CYK18; Cytokeratin 18; cytokeratin-18; K18; Keratin 18; keratin, type I cytoskeletal 18; keratin-18; KRT18
Mass (kDA):
48.058 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (52948871..52952906) |
Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.
Cytoplasm, perinuclear region. Nucleus, nucleolus.
PMID: 2434380 by Oshima R.G., et al. Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.
PMID: 2454392 by Kulesh D.A., et al. Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells.
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