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- Table of Contents
Facts about Keratin, type I cytoskeletal 17.
Modulates the role of TNF-alpha in the particular circumstance of hair cycling. Regulates protein synthesis and epithelial cell development through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway (By similarity).
Human | |
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Gene Name: | KRT17 |
Uniprot: | Q04695 |
Entrez: | 3872 |
Belongs to: |
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intermediate filament family |
39.1; CK-17; cytokeratin-17; K17; keratin 17; keratin, type I cytoskeletal 17; keratin-17; PC; PC2; PCHC1
Mass (kDA):
48.106 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (41619442..41624575, complement) |
Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).
Cytoplasm.
PMID: 1281771 by Troyanovsky S.M., et al. Characterization of the human gene encoding cytokeratin 17 and its expression pattern.
PMID: 1372562 by Flohr T., et al. Interferon-gamma regulates expression of a novel keratin class I gene.