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- Table of Contents
3 Citations 16 Q&As
Facts about Keratin, type I cytoskeletal 14.
Human | |
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Gene Name: | KRT14 |
Uniprot: | P02533 |
Entrez: | 3861 |
Belongs to: |
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intermediate filament family |
CK14; CK-14; Cytokeratin 14; cytokeratin-14; EBS3; EBS4; K14; keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner); keratin 14; keratin, type I cytoskeletal 14; keratin-14; KRT14; NFJ
Mass (kDA):
51.561 kDA
Human | |
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Location: | 17q21.2 |
Sequence: | 17; NC_000017.11 (41582279..41586895, complement) |
Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.
Cytoplasm. Nucleus. Expressed in both as a filamentous pattern.
PMID: 6210150 by Marchuk D., et al. Remarkable conservation of structure among intermediate filament genes.
PMID: 2580298 by Marchuk D., et al. Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.
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