KNTC1 Antibodies

AND KNTC1 ELISA kits, KNTC1 Proteins

Many biological assays use antibodies to detect KNTC1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KNTC1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KNTC1 antibodies...

We validate the specificity of these antibodies to KNTC1 by testing them on tissues known to express KNTC1 positively and negatively. Browse below to find the KNTC1 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: USP34

KNTC1 Infographic by Boster Bio

All KNTC1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

KNTC1 Overview

Facts about Kinetochore-associated protein 1.

KNTC1 3D structure. Source: alphafold

Kinetochore-associated protein 1 (KNTC1)

Essential component of the mitotic checkpoint, which prevents cells from exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes on kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131).

Its function linked to the spindle assembly machinery is proposed to rely on its association in the mitotic RZZ complex. .

Gene Information

Human
Gene Name:	KNTC1
Uniprot:	P50748
Entrez:	9735

Family

Belongs to:

No superfamily

Alternative Names

FLJ36151; hRod; hsROD; KIAA0166Rough Deal homolog, centromere/kinetochore protein; kinetochore associated 1; kinetochore-associated protein 1; Rod; RODHsROD; Rough deal homolog

Molecular Weight

Mass (kDA):
250.749 kDA

Genomic Context


Human

Location:	12q24.31
Sequence:	12; NC_000012.12 (122527106..122626409)

Tissue Specificity

High expression in testis.

Subcellular Localizations

Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Dynamic pattern of localization during the cell cycle. At interphase, uniformly distributed throughout the cytoplasm and nucleus. By prophase and until late stages of prometaphase, a fraction of the total pool is concentrated at kinetochores. By metaphase, detected at kinetochores, along spindle fibers and most prominently at the poles. By late anaphase until the end of telophase, no longer detectable on kinetochores or along spindle fibers, but still present at the spindle poles.

Diseases

Malignant Neoplasms
Neuroblastoma
Stomach Neoplasms
Mutation, Out-of-frame
Hepatitis, Chronic
Liver Carcinoma
Hepatitis
Hepatitis C, Chronic
High-frequency Microsatellite Instability
Microsatellite Instability
Tissue Adhesions
Hepatitis C
Carcinoma

Virus Diseases
Fibrosis
Malignant Neoplasm Of Stomach
Neoplasms
Nervousness
Colorectal Neoplasms
Metaplastic Cell Transformation

Interacting Proteins

ZWILCH

Pathways

Cell Cycle
Mitosis
Chromosome Segregation
Cell Proliferation
Spindle Checkpoint
Metaphase
Pathogenesis

Eye Development
Anaphase

PTMs

Phosphoprotein

Research Areas

Mitotic Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KNTC1

References

PMID: 11146660 by Chan G.K.T., et al. Human Zw10 and ROD are mitotic checkpoint proteins that bind to kinetochores.

PMID: 11590237 by Scaeerou F., et al. The ZW10 and Rough Deal checkpoint proteins function together in a large, evolutionarily conserved complex targeted to the kinetochore.