KMT2B Antibodies

AND KMT2B ELISA kits, KMT2B Proteins

Many biological assays use antibodies to detect KMT2B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KMT2B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KMT2B antibodies...

We validate the specificity of these antibodies to KMT2B by testing them on tissues known to express KMT2B positively and negatively. Browse below to find the KMT2B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KMT2B Infographic by Boster Bio

All KMT2B Products

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Product

Figures

Specificity

Applications

Price

Anti-WBP7 KMT2B Antibody

Human, Mouse, Rat

$405
Cat # A05680
100ul

Anti-MLL4 KMT2B Antibody

Human, Mouse

IHC

$380
Cat # A05680-1
100ul

KMT2B Overview

Facts about Histone-lysine N-methyltransferase 2B.

Histone-lysine N-methyltransferase 2B (KMT2B)

Histone methyltransferase. Methylates 'Lys-4' of histone H3.

H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2.

Gene Information

Human
Gene Name:	KMT2B
Uniprot:	Q9UMN6
Entrez:	9757

Family

Belongs to:

class V-like SAM-binding methyltransferase superfamily

Alternative Names

Histone-lysine N-methyltransferase 2B

Molecular Weight

Mass (kDA):
293.515 kDA

Genomic Context


Human

Location:	19q13.12
Sequence:	19; NC_000019.10 (35717818..35738878)

Tissue Specificity

Widely expressed. Highest levels in testis. Also found in brain with higher expression in the cerebellum than in any other region, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.

Subcellular Localizations

Nucleus.

Diseases

Dystonia 28, childhood-onset (DYT28)

Interacting Proteins

NCK1
NCOA6
WDR5

PTMs

Acetylation
Isopeptide bond

Phosphoprotein
Ubl conjugation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KMT2B

References

PMID: 10637508 by Huntsman D.G., et al. MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines.

PMID: 10409430 by FitzGerald K.T., et al. MLL2: a new mammalian member of the trx/MLL family of genes.