Krueppel-like factor 4 Antibodies

Krueppel-like factor 4 (KLF4)

Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence.

Binds to the promoter region of its gene and can activate its transcription. Regulates the expression of key transcription factors during embryonic development.

Gene Information

Human
Gene Name:	KLF4
Uniprot:	O43474
Entrez:	9314

Family

Belongs to:
krueppel C2H2-type zinc-finger protein family

Alternative Names

Epithelial zinc finger protein EZF; EZF; EZFendothelial Kruppel-like zinc finger protein; GKLFKrueppel-like factor 4; Gut-enriched krueppel-like factor; KLF4; Kruppel-like factor 4 (gut)

Molecular Weight

Mass (kDA):
54.671 kDA

Genomic Context

Human
Location:	9q31.2
Sequence:	9; NC_000009.12 (107484852..107489769, complement)

Subcellular Localizations

Nucleus.

Diseases

• Idiopathic Pneumonia Syndrome
• Malignant Neoplasms
• Neoplasms
• Teratoma
• Cell Transformation, Neoplastic
• Leukemia
• Carcinoma
• Malignant Tumor Of Colon
• Chimera Disorder
• Inflammation
• Malignant Paraganglionic Neoplasm
• Colorectal Cancer

• Neoplasm Metastasis
• Immunologic Deficiency Syndromes
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Colonic Neoplasms
• Cell Invasion
• Hyperplasia

Interacting Proteins

• CTBP1
• MBD3

Pathways

• Cell Proliferation
• Cell Differentiation
• Cell Cycle
• Methylation
• Pathogenesis
• Cell Growth
• Dna Methylation
• Regeneration
• Localization
• Cell Cycle Arrest
• Chromatin Remodeling
• Senescence
• Angiogenesis

• Cell Migration
• Cell Adhesion
• Cell Development
• Cell Death
• Translation
• Immune Response
• Demethylation

PTMs

• Methylation
• Phosphorylation
• Acetylation
• Demethylation
• Deacetylation

• Cleavage
• Ubiquitination
• Sumoylation
• Reduction
• Oxidation

• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLF4

Best Uses Of The KLF4 Marker

KLF4 is an transcription factor that contains zinc finger that has been found to be evolutionarily conserved. It regulates the differentiation of thymocytes and cell survival and inhibits apoptosis. It also regulates cell apoptosis through activation of the noncoding RNA metastasis-associated lung adenocarcinoma transcript 138.

KLF4 is an evolutionarily conserved zinc finger transcription factor.

The Kruppel-like factor 4 (KLF4) family is a diverse group of transcription factors that regulate many biological processes. It was first discovered in 1996. In 2006, it was found to be one of the four transcription factors involved in pluripotent stem cell induction. In an earlier review we reviewed the role of KLF4 in various tissues and also discussed its role in various illnesses.

The mechanism behind KLF4's role in reprogramming remains unexplored, it has been involved in the regulation of various important processes that include cell division and the cell cycle. KLF4 has been linked with a variety of significant diseases and disorders, including the cancer. These findings show the importance of KLF4 in these diseases. We hope that this research will help us understand its role in causing disease.

KLFs are closely associated with the Sp family of zinc finger transcription factors, and there are nine in the human genome. KLFs possess a variety of N-terminal regulatory domains, as well as a recurrent C-terminal DNA-binding motif. In addition these proteins are able to connect to GC-rich sequences, such as CACCC elements that are found in proximal promoters of many eukaryotic genes.

It regulates thymocyte proliferation

Kruppel-like transcription factor 4 (KLF4), which is an element of transcription that is zinc finger-bound is a conserved evolutionary gene. It regulates many cell processes. In 2006, it was discovered to be one of the four crucial transcription factors in the process of generating pluripotent stem cells. We will now examine the role played by this protein in various cells and tissues. We will also discuss the role played by KLF4 for thymocyte development.

While the KLF4 gene is expressed in many tissues throughout the development process It is particularly expressed in mouse erythroid cells. It regulates macrophage activation when LPS is applied. It also inhibits IL1b expression and promotes HMGB1, a late inflammatory mediator. Additionally, KLF4 regulates monocyte differentiation and B-cell proliferation. It also regulates B-cell number. It is also a major player in the process of embryonic erythropoiesis.

The SP/KLF family comprises the KLF4 gene. It has three zinc fingers motif and two transactivation and repression domains. These domains are responsible for the specificity and efficiency of its transcriptional regulating activities. KLF4 also affects DNA binding efficiency. Two nuclear localization signals exist in the mouse KLF4 gene. They cover its first and second zinc finger domains.

It is a key factor in promoting survival by suppressing the apoptosis process.

It helps to prolong life by reducing an apoptosis-like pop. Apoptosis is the term used to describe the process through which a cell dies. Apoptosis is a process that can be stopped so that cells can divide and live. This process can be reversed, and cell rescue or mutagenesis can be accomplished. Reversing apoptosis could be vital for many cell functions.

Survival factors serve as growth factors within cells and stop Apoptosis via activation of the serine/threonine kinase, Akt. This enzyme phosphorylates elements of the apoptotic machine which include BAD, Caspase 9, and Fas ligand. It regulates FKHRL1 which is a member of the Forkhead family of transcription factors. This triggers nuclear translocation of Fas the ligand gene and inhibits apoptosis.

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