Krueppel-like factor 15 Antibodies

AND KLF15 ELISA kits, Krueppel-like factor 15 Proteins

Many biological assays use antibodies to detect Krueppel-like factor 15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Krueppel-like factor 15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Krueppel-like factor 15 antibodies...

We validate the specificity of these antibodies to Krueppel-like factor 15 by testing them on tissues known to express KLF15 positively and negatively. Browse below to find the KLF15 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KLF15 Infographic by Boster Bio

All KLF15 Products

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Product

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Specificity

Applications

Price

Anti-Krueppel-like factor 15 KLF15 Monoclonal Antibody

Human

ELISA, WB

$380
Cat # M03661
100ul

Anti-KLF15 Antibody Picoband®

Human, Mouse, Rat

ELISA, IHC, WB

$370
Cat # A03661-1
100 μg/vial

KLF15 (NM_014079) Human Over-expression Lysate

Human

$628
Cat # LS028999
100 µg

KLF15 Overview

Facts about Krueppel-like factor 15.

KLF15 3D structure. Source: alphafold

Krueppel-like factor 15 (KLF15)

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the center (By similarity).

Is a repressor of CTGF expression, involved in the management of cardiac fibrosis. It is also involved in the management of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity).

Gene Information

Human
Gene Name:	KLF15
Uniprot:	Q9UIH9
Entrez:	28999

Family

Belongs to:

Sp1 C2H2-type zinc-finger protein family

Alternative Names

DKFZp779M1320; kidney-enriched Kruppel-like factor; KKLFKidney-enriched krueppel-like factor; Krueppel-like factor 15; Kruppel-like factor 15

Molecular Weight

Mass (kDA):
43.992 kDA

Genomic Context


Human

Location:	3q21.3
Sequence:	3; NC_000003.12 (126288121..126357408, complement)

Tissue Specificity

Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.

Subcellular Localizations

Nucleus.

Diseases

Hypertrophy
Obesity
Heart Failure
Insulin Resistance
Diabetes Mellitus
Cardiac Hypertrophy
Fibrosis
Inflammation
Kidney Diseases
Facial Paralysis
Malignant Neoplasms
Chronic Kidney Disease

Mammary Neoplasms
Diabetes Mellitus, Non-insulin-dependent
Glomerulosclerosis (disorder)
Stenosis
Left Ventricular Hypertrophy
Hyperglycemia
Proteinuria Of Undiagnosed Cause

Interacting Proteins

PRKAB2
ZBTB24

Pathways

Transport
Localization
Gluconeogenesis
Glucose Transport
Glucose Homeostasis
Cell Cycle
Cell Differentiation
Cell Proliferation
Energy Homeostasis
Dna Replication
Regulation Of Gluconeogenesis
Cell Growth
Pathogenesis

Hyperphosphorylation
Brain Development
Aging
Neurogenesis
Regulation Of Gene Expression
Oxidative Phosphorylation
Chondrocyte Hypertrophy

PTMs

Phosphorylation
Acetylation

Oxidation
Deacetylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KLF15

References

PMID: 10982849 by Uchida S., et al. Transcriptional regulation of the CLC-K1 promoter by myc-associated zinc finger protein and kidney-enriched Kruppel-like factor, a novel zinc finger repressor.

PMID: 17438289 by Fisch S., et al. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy.