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- Table of Contents
Facts about Killer cell immunoglobulin-like receptor 2DS5.
Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).
Human | |
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Gene Name: | KIR2DS5 |
Uniprot: | Q14953 |
Entrez: | 3810 |
Belongs to: |
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immunoglobulin superfamily |
killer cell immunoglobulin-like receptor 2DS5; CD158g; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5; KIR2DS5; NKAT9
Mass (kDA):
33.698 kDA
Human | |
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Location: | 19q13.4 |
Sequence: | 19; NT_187668.1 (105956..120932, complement) |
Expressed on a discrete subset of peripheral blood NK cells.
Cell membrane; Single-pass type I membrane protein; Extracellular side.
PMID: 8662091 by Doehring C., et al. Alternatively spliced forms of human killer inhibitory receptors.
PMID: 28569259 by Roe D., et al. Revealing complete complex KIR haplotypes phased by long-read sequencing technology.