Killer cell immunoglobulin-like receptor 2DS5 (KIR2DS5)

Activating natural killer (NK) receptor which recognizes C2 epitopes of HLA-C alleles. Bridging the innate and adaptive immune systems, NK cells express several cell surface receptors that inhibit or stimulate their cytotoxicity (PubMed:28685972, PubMed:18624290, PubMed:18682925).

Able to activate NK cells citotoxicity and cytokine production such as IFNG (PubMed:18624290, PubMed:24269691). Receptor functions are attenuated even lost in some alleles, such as KIR2DS5*002 reprensented in this entry (PubMed:28685972).