KDM5B Antibodies

AND KDM5B ELISA kits, KDM5B Proteins

Many biological assays use antibodies to detect KDM5B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KDM5B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KDM5B antibodies...

We validate the specificity of these antibodies to KDM5B by testing them on tissues known to express KDM5B positively and negatively. Browse below to find the KDM5B antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KDM5B Infographic by Boster Bio

All KDM5B Products

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Product

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Specificity

Applications

Price

Anti-KDM5B/PLU1/Jarid1B Antibody Picoband®

3 Q&As

Human, Monkey, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB10073
100 μg/vial

KDM5B (NM_006618) Human Over-expression Lysate

Human

$960
Cat # LS010765
100 µg

KDM5B Overview

Facts about Lysine-specific demethylase 5B.

KDM5B 3D structure. Source: alphafold

Lysine-specific demethylase 5B (KDM5B)

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3'Lys-9' or' H3'Lys-27'.

Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9.

Gene Information

Human
Gene Name:	KDM5B
Uniprot:	Q9UGL1
Entrez:	10765

Family

Belongs to:

JARID1 histone demethylase family

Alternative Names

CT31; CT31FLJ10538; EC 1.14.11; EC 1.14.11.-; homolog 1A; Jarid1B; JARID1BFLJ16281; Jumonji, AT rich interactive domain 1B (RBP2-like); jumonji, AT rich interactive domain 1B; KDM5B; Lysine (K)specific Demethylase 5B; Lysine (K)-specific Demethylase 5B; PLU-1; PLU-1FLJ12459; PLU1FLJ23670; PUT1; RBBP2H1; RBBP2H1AFLJ12491; RBP2-H1; Retinoblastoma-binding protein 2 homolog 1

Molecular Weight

Mass (kDA):
175.658 kDA

Genomic Context


Human

Location:	1q32.1
Sequence:	1; NC_000001.11 (202724495..202809470, complement)

Tissue Specificity

Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level).

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Melanoma
Retinoblastoma
Cell Transformation, Neoplastic
Neoplasm Metastasis
Malignant Neoplasm Of Lung
Cell Invasion
Skin Neoplasms

Retinal Dystrophies
Non-neoplastic Disorder
Neoplasm Invasiveness
Malignant Neoplasm Of Urinary Bladder
Carcinoma

Interacting Proteins

CTCF

Pathways

Demethylation
Methylation
Histone Methylation
Cell Cycle
Cell Proliferation
Chromatin Remodeling
Cellular Senescence
Histone Modification
Cell Cycle Arrest
Cell Differentiation
Histone Lysine Methylation
Localization
Senescence

Cell Migration
Gene Silencing
Dna Hypermethylation
Brain Development
Dna Demethylation
M Phase
Spermatogenesis

PTMs

Methylation
Demethylation

Acetylation
Phosphorylation

Hydroxylation

Research Areas

Epigenetics

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KDM5B

References

PMID: 10336460 by Lu P.J., et al. A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.

PMID: 10616211 by Vogt T., et al. Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer.