Lysine-specific demethylase 2B (Kdm2b)

Histone demethylase that demethylates'Lys-4' and'Lys- 36' of histone H3, thereby playing a fundamental role in histone code. Preferentially demethylates trimethylated H3'Lys-4' and dimethylated H3'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3'Lys-36'.

Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition part of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.