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KCNQ2 Antibodies
AND KCNQ2 ELISA kits, KCNQ2 Proteins
Many biological assays use antibodies to detect KCNQ2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNQ2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNQ2 antibodies...
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KCNQ2 Infographic by Boster Bio
All KCNQ2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IHC
$380
Cat # A01259T217
100ul
Cat # A01259T217
100ul
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A01259-1
100 μg/vial
Cat # A01259-1
100 μg/vial
KCNQ2 Overview
Facts about Potassium voltage-gated channel subfamily KQT member 2.
Potassium voltage-gated channel subfamily KQT member 2 (KCNQ2)
Associates with KCNQ3 to form a potassium channel with basically identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in setting the subthreshold electrical excitability of neurons in addition to the responsiveness to synaptic inputs. Therefore, it's important in the regulation of neuronal excitability.
KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and triggered by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 can also be suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873).
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNQ2 |
| Uniprot: | O43526 |
| Entrez: | 3785 |
Family
| Belongs to: |
|---|
| potassium channel family |
Alternative Names
BFNC; BFNS1; EBN; EBN1; EIEE7; ENB1; HNSPC; KCNA11; KQT-like 2; Kv7.2; KVEBN1; neuroblastoma-specific potassium channel protein; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; potassium voltage-gated channel subfamily KQT member 2; potassium voltage-gated channel, KQT-like subfamily, member 2; Voltage-gated potassium channel subunit Kv7.2
Molecular Weight
Mass (kDA):
95.848 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.33 |
| Sequence: | 20; NC_000020.11 (63400208..63472655, complement) |
Tissue Specificity
In adult and fetal brain. Highly expressed in areas containing neuronal cell bodies, low in spinal chord and corpus callosum. Isoform 2 is preferentially expressed in differentiated neurons. Isoform 6 is prominent in fetal brain, undifferentiated neuroblastoma cells and brain tumors.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Epilepsy
- Convulsion Neonatal
- Familial Benign Neonatal Epilepsy
- Convulsions
- Benign Neonatal Epilepsy
- Epilepsy, Generalized
- Pain
- Nervousness
- Febrile Convulsions
- Myokymia
- Channelopathies
- Epilepsies, Myoclonic
Pathways
- Pathogenesis
- Localization
- Membrane Depolarization
- Transport
- Cognition
- Hypersensitivity
- Exocytosis
- Brain Development
- Sensitization
- Glycosylation
- Lipid Phosphorylation
- Protein Phosphorylation
- Muscle Contraction
PTMs
- Phosphorylation
- Reduction
- Glycosylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNQ2
bosterbio.com/bosterbio-gene-info-cards/KCNQ2
References
PMID: 9039501 by Yokoyama M., et al. Identification and cloning of neuroblastoma-specific and nerve tissue-specific genes through compiled expression profiles.
PMID: 9425895 by Singh N.A., et al. A novel potassium channel gene, KCNQ2, is mutated in an inherited epilepsy of newborns.