KCNQ1 Antibodies

AND KCNQ1 ELISA kits, KCNQ1 Proteins

Many biological assays use antibodies to detect KCNQ1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNQ1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNQ1 antibodies...

We validate the specificity of these antibodies to KCNQ1 by testing them on tissues known to express KCNQ1 positively and negatively. Browse below to find the KCNQ1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNQ1 Infographic by Boster Bio

All KCNQ1 Products

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Specificity

Applications

Price

Anti-KCNQ1 Antibody Picoband®

1 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A00310-1
100 μg/vial

Anti-Kv7.1 KCNQ1 Antibody

Human, Mouse, Rat

$405
Cat # A00310
100ul

KCNQ1 Overview

Facts about Potassium voltage-gated channel subfamily KQT member 1.

KCNQ1 3D structure. Source: alphafold

Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)

Potassium channel that plays an important role in several of tissues, such as heart, internal ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231).

Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification feature (By similarity).

Gene Information

Human
Gene Name:	KCNQ1
Uniprot:	P51787
Entrez:	3784

Family

Belongs to:

potassium channel family

Alternative Names

ATFB3; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; JLNS1; KCNA8FLJ26167; KCNA9Kv1.9; kidney and cardiac voltage dependend K+ channel; KQT-like 1; Kv7.1; KVLQT1ATFB1; LQT; LQT1; potassium voltage-gated channel subfamily KQT member 1; potassium voltage-gated channel, KQT-like subfamily, member 1; RWS; slow delayed rectifier channel subunit; SQT2; Voltage-gated potassium channel subunit Kv7.1; WRS

Molecular Weight

Mass (kDA):
74.699 kDA

Genomic Context


Human

Location:	11p15.5-p15.4
Sequence:	11; NC_000011.10 (2445008..2849110)

Tissue Specificity

Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Early endosome. Membrane raft. Endoplasmic reticulum. Basolateral cell membrane. Colocalized with KCNE3 at the plasma membrane (PubMed:10646604). Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome (PubMed:23529131). Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains (PubMed:24855057). During the early stages of epithelial cell polarization induced by the calcium switch it removed from plasma membrane to the endoplasmic reti

Diseases

Long Qt Syndrome
Cardiac Arrhythmia
Sudden Death
Syncope
Sudden Cardiac Death
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Long Qt Syndrome Congenital
Cardiac Fibrillation
Complete Hearing Loss
Torsades De Pointes
Cardiac Death
Romano-ward Syndrome

Atrial Fibrillation
Jervell-lange Nielsen Syndrome
Tachycardia, Ventricular
Heart Diseases
Beckwith-wiedemann Syndrome
Cardiac Arrest
Ventricular Fibrillation

Interacting Proteins

KCNE1

Pathways

Secretion
Transport
Methylation
Localization
Acid Secretion
Pathogenesis
Gastric Acid Secretion
Dna Methylation
Insulin Secretion
Ion Transport
Cell Proliferation
Membrane Depolarization
Swimming

Glycosylation
Fertilization
Excretion
Reverse Transcription
Aging
Regulation Of Gastric Acid Secretion
Spermatogenesis

PTMs

Methylation
Phosphorylation
Reduction
Glycosylation
Demethylation
Biotinylation

Ubiquitination
Nitrosylation
Carboxylation
Deacetylation
Cleavage
Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNQ1

References

PMID: 9312006 by Chouabe C., et al. Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias.

PMID: 9305853 by Jiang M., et al. Suppression of slow delayed rectifier current by a truncated isoform of KvLQT1 cloned from normal human heart.