KCNN2 Antibodies

AND KCNN2 ELISA kits, KCNN2 Proteins

Many biological assays use antibodies to detect KCNN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNN2 antibodies...

We validate the specificity of these antibodies to KCNN2 by testing them on tissues known to express KCNN2 positively and negatively. Browse below to find the KCNN2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNN2 Infographic by Boster Bio

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KCNN2 (NM_021614) Human Over-expression Lysate

Human

$960
Cat # LS003781
100 µg

KCNN2 Overview

Facts about Small conductance calcium-activated potassium channel protein 2.

KCNN2 3D structure. Source: alphafold

Small conductance calcium-activated potassium channel protein 2 (KCNN2)

Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization.

Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin.

Gene Information

Human
Gene Name:	KCNN2
Uniprot:	Q9H2S1
Entrez:	3781

Family

Belongs to:

potassium channel KCNN family

Alternative Names

hSK2; KCa2.2SKCA2; potassium intermediate/small conductance calcium-activated channel, subfamilyN, member 2; SK2apamin-sensitive small-conductance Ca2+-activated potassium channel; SKCa 2; SKCa2; small conductance calcium-activated potassium channel protein 2

Molecular Weight

Mass (kDA):
63.76 kDA

Genomic Context


Human

Location:	5q22.3
Sequence:	5; NC_000005.10 (114055978..114496500)

Tissue Specificity

Expressed in atrial myocytes (at protein level). Widely expressed.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Nervousness
Epilepsy
Cardiac Arrhythmia
Malnutrition
Neoplasms
Pain
Cardiac Fibrillation
Impaired Cognition
Memory Disorders
Memory Impairment
Atrial Fibrillation
Brain Ischemia

Ataxia
Swine Diseases
Acquired Kyphosis
Sarcoma
Carcinoma
Epilepsy, Reflex
Malignant Neoplasms

Interacting Proteins

ACTN2

Pathways

Localization
Innervation
Secretion
Translation
Exocytosis
Membrane Hyperpolarization
Cell Death
Pathogenesis
Transport
Regulation Of Secretion
Reflex
Reverse Transcription
Cognition

Hormone Secretion
Cell Proliferation
Insulin Secretion
Endocytic Recycling
Synaptic Transmission
Endocytosis
Respiratory Burst

PTMs

Phosphorylation

Reduction

Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNN2

References

PMID: 10991935 by Desai R., et al. Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization.

PMID: 13679367 by Xu Y., et al. Molecular identification and functional roles of a Ca(2+)-activated K+ channel in human and mouse hearts.