ATP-sensitive inward rectifier potassium channel 12 (KCNJ12)

Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate which probably participates in controlling the resting membrane potential in excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues.

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages.