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Calsenilin Antibodies
AND KCNIP3 ELISA kits, Calsenilin Proteins
Many biological assays use antibodies to detect Calsenilin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Calsenilin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Calsenilin antibodies...
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KCNIP3 Infographic by Boster Bio
All KCNIP3 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1076
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1076
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2283
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2283
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, IF, IHC, WB
$380
Cat # A03700S63
100ul
Cat # A03700S63
100ul
Human, Mouse, Rat
WB
$523
Cat # M03700
100 µl
Cat # M03700
100 µl
KCNIP3 Overview
Facts about Calsenilin.
Calsenilin (KCNIP3)
Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium.
Appears to be involved in nociception (By similarity). .
Gene Information
| Human | |
|---|---|
| Gene Name: | KCNIP3 |
| Uniprot: | Q9Y2W7 |
| Entrez: | 30818 |
Family
| Belongs to: |
|---|
| recoverin family |
Alternative Names
calsenilin; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN MGC18289; DREAM; DREAMA-type potassium channel modulatory protein 3; KCHIP3 DRE-antagonist modulator; KChIP3; Kv channel interacting protein 3, calsenilin; Kv channel-interacting protein 3; potassium channel interacting protein 3
Molecular Weight
Mass (kDA):
29.231 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q11.1 |
| Sequence: | 2; NC_000002.12 (95297325..95386077) |
Tissue Specificity
Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.
Subcellular Localizations
Cytoplasm. Cell membrane; Lipid-anchor. Endoplasmic reticulum. Golgi apparatus. Nucleus. Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus.
Diseases
- Alzheimer's Disease
- Neuroblastoma
- Malignant Neoplasms
- Neoplasms
- Pain
- Epilepsy
- Alzheimer Disease, Familial
- Neurodegenerative Disorders
- Carcinoma
- Nerve Degeneration
- Retinoblastoma
- Malignant Neoplasm Of Thyroid
- Brain Ischemia
Interacting Proteins
- CD177
- IGF1R
- IL6ST
- MAVS
- SOD3
Pathways
- Cell Death
- Localization
- Cell Cycle
- Mitosis
- Regulation Of Gene Expression
- S Phase
- Secretion
- Induction Of Apoptosis
- Immune Response
- Tropism
- Chromosome Segregation
- Anaphase
- Cytokinesis
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Vision
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNIP3
bosterbio.com/bosterbio-gene-info-cards/KCNIP3
References
PMID: 9771752 by Buxbaum J.D., et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment.
PMID: 10078534 by Carrion A.M., et al. DREAM is a Ca2+-regulated transcriptional repressor.