Potassium voltage-gated channel subfamily B member 1 (KCNB1)

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the mind, but also in the pancreas and cardiovascular system. Contributes to the regulation of the action potential (AP) repolarization, length and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain (PubMed:23161216).

Plays also a part in the regulation of exocytosis independently of its electric function (By similarity). Forms tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient.