KCNAB2 Antibodies

AND KCNAB2 ELISA kits, KCNAB2 Proteins

Many biological assays use antibodies to detect KCNAB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNAB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNAB2 antibodies...

We validate the specificity of these antibodies to KCNAB2 by testing them on tissues known to express KCNAB2 positively and negatively. Browse below to find the KCNAB2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNAB2 Infographic by Boster Bio

All KCNAB2 Products

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Kv beta 2 (KCNAB2) (NM_003636) Human Recombinant Protein

$813
Cat # PROTQ13303
20 µg

Kv beta 2 (KCNAB2) (NM_003636) Human Over-expression Lysate

Human

$628
Cat # LS008514
100 µg

KCNAB2 Overview

Facts about Voltage-gated potassium channel subunit beta-2.

KCNAB2 3D structure. Source: alphafold

Voltage-gated potassium channel subunit beta-2 (KCNAB2)

Cytoplasmic potassium channel subunit that modulates the qualities of this channel-forming alpha-subunits (PubMed:7649300, PubMed:11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity).

Promotes expression of this pore-forming alpha subunits at the cell membrane, and thereby increases channel activity (By similarity). Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore (PubMed:7649300, PubMed:11825900).

Gene Information

Human
Gene Name:	KCNAB2
Uniprot:	Q13303
Entrez:	8514

Family

Belongs to:

shaker potassium channel beta subunit family

Alternative Names

HKvbeta2; HKvbeta2.1; HKvbeta2.2; K(+) channel subunit beta-2; K+ channel beta-2 subunit; KCNA2BAKR6A5; KCNK2; KV-BETA-2; MGC117289; potassium channel shaker chain beta 2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2

Molecular Weight

Mass (kDA):
41 kDA

Genomic Context


Human

Location:	1p36.31
Sequence:	1; NC_000001.11 (5992639..6101186)

Tissue Specificity

Detected in myelinated nerve fibers in the spinal cord, in the juxtaparanodal region of the nodes of Ranvier, but also in the paranodal region (PubMed:11086297). Detected in hippocampus (at protein level) (PubMed:21357749). Detected in hippocampus (PubMed:7649300).

Subcellular Localizations

Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, axon. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. Associates with microtubules when unphosphorylated.

Diseases

1p36 Deletion Syndrome
Epilepsy
Nervousness
Spasm
Haploinsufficiency
Tremor, Unspecified
Monosomy
Congenital Heart Defects
Vascular Diseases
Hyperplasia
Brain Ischemia

Metabolic Acidosis
Diabetic Neuropathies
Hemorrhage
Neoplasms
Pathologic Vasoconstriction
Chromosomal Deletion

Pathways

Transport
Localization
Cell Adhesion
Smooth Muscle Cell Proliferation
Muscle Cell Proliferation
Cell Proliferation
Glycosylation
Immune Response
Ion Transport
Associative Learning
Protein Transport

Neuroprotection
Lipid Oxidation
Cell Death
Membrane Repolarization
Chromatin Remodeling

PTMs

Phosphorylation

Glycosylation

Oxidation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNAB2

References

PMID: 7649300 by Mccormack K., et al. Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product.

PMID: 11086297 by Rasband M.N., et al. Subunit composition and novel localization of K+ channels in spinal cord.