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- Table of Contents
Facts about Potassium voltage-gated channel subfamily A member 5.
The station alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form operational homotetrameric channels and heterotetrameric channels which contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members too; station properties depend on the sort of alpha subunits which are part of the station (PubMed:12130714).
Human | |
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Gene Name: | KCNA5 |
Uniprot: | P22460 |
Entrez: | 3741 |
Belongs to: |
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potassium channel family |
HK2; insulinoma and islet potassium channel; PCN1; potassium channel 1; potassium voltage-gated channel, shaker-related subfamily, member 5; voltage-gated potassium channel HK2
Mass (kDA):
67.228 kDA
Human | |
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Location: | 12p13.32 |
Sequence: | 12; NC_000012.12 (5043879..5046788) |
Pancreatic islets and insulinoma.
Cell membrane; Multi-pass membrane protein.
PMID: 2001794 by Tamkun M.M., et al. Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle.
PMID: 1986382 by Philipson L.H., et al. Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel.