KCNA2 Antibodies

AND KCNA2 ELISA kits, KCNA2 Proteins

Many biological assays use antibodies to detect KCNA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNA2 antibodies...

We validate the specificity of these antibodies to KCNA2 by testing them on tissues known to express KCNA2 positively and negatively. Browse below to find the KCNA2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNA2 Infographic by Boster Bio

All KCNA2 Products

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Product

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Specificity

Applications

Price

Anti-Kv1.2/KCNA2 Antibody Picoband®

4 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # PB9649
100 μg/vial

Kv1.2 (KCNA2) (NM_004974) Human Recombinant Protein

$813
Cat # PROTP16389
20 µg

Kv1.2 (KCNA2) (NM_004974) Human Over-expression Lysate

Human

$960
Cat # LS003737
100 µg

KCNA2 Overview

Facts about Potassium voltage-gated channel subfamily A member 2.

KCNA2 3D structure. Source: alphafold

Potassium voltage-gated channel subfamily A member 2 (KCNA2)

Voltage-gated potassium channel that mediates transmembrane potassium transfer in excitable membranes, primarily in the brain and the central nervous system, but also from the cardiovascular system. Prevents aberrant action potential firing and modulates neuronal output.

Types tetrameric potassium- selective channels through which potassium ions pass in accordance with their electrochemical gradient. The station alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:19912772, PubMed:8495559, PubMed:11211111, PubMed:23769686).

Gene Information

Human
Gene Name:	KCNA2
Uniprot:	P16389
Entrez:	3737

Family

Belongs to:

potassium channel family

Alternative Names

EC 3.6.1.27; EC 6.1.1; HBK5; HK4; HUKIV; KV1.2; MGC50217; MK2; NGK1; potassium channel; potassium voltage-gated channel subfamily A member 2; potassium voltage-gated channel, shaker-related subfamily, member 2; RBK2; Voltage-gated K(+) channel HuKIV; Voltage-gated potassium channel HBK5; voltage-gated potassium channel protein Kv1.2; Voltage-gated potassium channel subunit Kv1.2

Molecular Weight

Mass (kDA):
56.717 kDA

Genomic Context


Human

Location:	1p13.3
Sequence:	1; NC_000001.11 (110593580..110631536, complement)

Tissue Specificity

Detected in brain cortex (PubMed:16473933). Detected in peroneal nerve in the juxtaparanodal regions of the node of Ranvier; expression is decreased in patients with diabetes mellitus that suffer from axonal neuropathy (PubMed:22649228). Detected in paranodal and juxtanodal zones in myelinated spinal cord (at protein level) (PubMed:11086297).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Membrane. Cell projection, axon. Cell junction, synapse. Endoplasmic reticulum membrane. Cell projection, lamellipodium membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, presynaptic cell membrane. Cell projection, dendrite. Cell junction, paranodal septate junction. KCNA2 by itself is detected both at the endoplasmic reticulum and at the cell membrane. Coexpression with KCNA4 or with beta subunits promotes expression at the cell membrane. Coexpression with KCNA1 inhibits cell surface expression. In myelinated peripheral axons, cl