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- Table of Contents
Facts about Histone acetyltransferase KAT2B.
Inhibits cell-cycle progression and counteracts the mitogenic action of the adenoviral oncoprotein E1A. Acts as a circadian transcriptional coactivator which enhances the action of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK- ARNTL/BMAL1 heterodimers.
Human | |
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Gene Name: | KAT2B |
Uniprot: | Q92831 |
Entrez: | 8850 |
Belongs to: |
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acetyltransferase family |
CREBBP-associated factor; EC 2.3.1.48; GCN5; GCN5L; Histone acetylase PCAF; histone acetyltransferase KAT2B; Histone acetyltransferase PCAF; K(lysine) acetyltransferase 2B; KAT2B; Lysine acetyltransferase 2B; P; P/CAFGCN5; P300/CBP-associated factorCAF; PCAF
Mass (kDA):
93.013 kDA
Human | |
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Location: | 3p24.3 |
Sequence: | 3; NC_000003.12 (20040407..20154404) |
Ubiquitously expressed but most abundant in heart and skeletal muscle.
Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255).
PMID: 8684459 by Yang X.-J., et al. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A.
PMID: 8945521 by Ogryzko V.V., et al. The transcriptional coactivators p300 and CBP are histone acetyltransferases.