Tyrosine-protein kinase JAK3 (JAK3)

Non-receptor tyrosine kinase involved in various processes like cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development.

In the cytoplasm, plays a pivotal role in signal transduction through its association with type I receptors sharing the frequent subunit gamma like IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of this receptor, creating docking sites for STATs proteins.