Protein jagged-2 Antibodies

Protein jagged-2 (JAG2)

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).

. .

Gene Information

Human
Gene Name:	JAG2
Uniprot:	Q9Y219
Entrez:	3714

Family

Belongs to:
No superfamily

Alternative Names

HJ2; JAG2; Jagged 2; Jagged2; protein jagged-2; SER2

Molecular Weight

Mass (kDA):
133.367 kDA

Genomic Context

Human
Location:	14q32.33
Sequence:	14; NC_000014.9 (105140981..105168776, complement)

Tissue Specificity

Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney.

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Malignant Neoplasms
• Neoplasms
• Cell Transformation, Neoplastic
• Cleft Palate
• Carcinoma
• Leukemia
• Congenital Abnormality
• Nervousness
• Malignant Neoplasm Of Breast
• Malignant Neoplasm Of Stomach
• Carcinogenesis
• Hyperplasia
• Neoplasm Metastasis

• Tumor Angiogenesis
• Tissue Adhesions
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Pancreas
• Inflammation
• Multiple Myeloma
• Tumor Progression

Interacting Proteins

• GFI1B

Pathways

• Notch Signaling Pathway
• Cell Differentiation
• Cell Proliferation
• Cell Development
• Cell Fate Specification
• Angiogenesis
• Lateral Inhibition
• Cell Fate Determination
• Neurogenesis
• Cell Cycle
• Regeneration
• Cell Growth
• Hair Cell Differentiation

• Secretion
• Gliogenesis
• Pathogenesis
• Brain Development
• Proteolysis
• Localization
• Cell Activation

PTMs

• Cleavage
• Phosphorylation

• Glycosylation
• Acetylation

• Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAG2

Boster Bio - Best Uses Of The JAG2 Marker

If you're looking for the best boster gene antibody to choose from, you can't go past the JAG2 Marker. Boster's high-affinity primary antibodies have been widely cited in the literature for over 25 years and have been thoroughly validated for use in Western Blotting, Immunohistochemistry, and ELISA. In the end, they are regarded as reliable by researchers.

Boster Bio Anti-Protein jagged-2 JAG2 Marker

Boster Bio Anti-Protein jagged-2 JAG2 marker is an extremely specific, sensitive antibody. This antibody can be used in ELISA and WB tests. It is extremely specific and has been validated for use in Flow Cytometry and IHC. It reacts with mouse, human, the rat, and zebrafish.

When JAG2 is expressed in colorectal cancer cells, it promotes cell invasion and migration. It interacts with the Notch signaling pathway, which affects EMT. Paracrine activity in exosomes is responsible for the fusion of JAG2 with Notch signaling. The combination of these molecules could also influence cell motility and invasion.

This antibody is extremely sensitive and specific for JAG2. It has been used for a variety of research applications, including immunohistochemistry, tumor markers, and in vitro diagnostics. It recognizes JAG2 as a major player in the development of colorectal cancer. It is well-known that it plays a role in cancer cell invasion and migration, and is positively linked to clinical stage. It promotes invasion, a process similar to glioma. It is also found in epithelial-mesenchymal transition markers.

According to some reports, JAG2 is associated w/ tumor cells and promotes expression of PRAF2 and exosomes. It is unclear whether JAG2 plays a biological role in other types of cancer cells. A recent study published in the Journal of Cell Biology shows that JAG2 is a key factor in the growth of cancer. It is therefore important to understand the function of this protein.

The HMJ2-1 monoclonal antibody reacts with mouse Jagged 2. The antibody is among the Notch ligands. The antibodies are able to neutralize Jagged2 in vivo. The HMJ2-1 anti-JAG2 Marker should be stored at 4degC. Do not freeze immunoglobulin IgG antibodies. These antibodies can be used in cancer research by analysing the function of Jagged2 pathways.

Boster Bio Anti-Bax Antibody Picoband

The anti-Bax antibody, which is a monoclonal monoclonal polyclonal, 5A6 specific monoclonal antibody, reacts to human PPID and monkey PPID. It is standardized for Flow Cytometry and Immunofluorescence , and is suitable for a range of applications. The product has been thoroughly tested and validated in a variety of tests including Immunofluorescence. The company's antibodies have been tested by IHC-P and flow cytometry and have been approved for a variety of applications. The company offers an unconditional quality guarantee on every product. The company is constantly expanding its product range every month and has a long history with happy customers.