IL2RA Antibodies

Interleukin-2 receptor subunit alpha (IL2RA)

Receptor for interleukin-2.

The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

TREGs suppress the activation and expansion of autoreactive T-cells. .

Gene Information

Human
Gene Name:	IL2RA
Uniprot:	P01589
Entrez:	3559

Family

Belongs to:
No superfamily

Alternative Names

CD25 antigen; CD25; IDDM10; IL-2 R alpha; IL-2 receptor subunit alpha; IL2R alpha; IL-2R subunit alpha; IL2R; IL2RA; IL-2Ra; IL-2-RA; IL2-RA; interleukin 2 receptor, alpha; interleukin-2 receptor subunit alpha; p55; TAC antigen; TCGFR

Molecular Weight

Mass (kDA):
30.819 kDA

Genomic Context

Human
Location:	10p15.1
Sequence:	10; NC_000010.11 (6010689..6062367, complement)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

• Autoimmune Reaction
• Autoimmune Diseases
• Neoplasms
• Malignant Neoplasms
• Diabetes Mellitus
• Inflammation
• Diabetes Mellitus, Insulin-dependent
• Sclerosis
• Autoimmunity
• Multiple Sclerosis
• Decreased Immunologic Activity [pe]
• Arthritis
• Leukemia

• Infective Disorder
• Graft-vs-host Disease
• Rheumatoid Arthritis
• Carcinoma
• Lymphoma
• Hepatitis
• Lupus Erythematosus, Systemic

Interacting Proteins

• IL2

Pathways

• Pathogenesis
• Immune Response
• Cell Proliferation
• Secretion
• T Cell Proliferation
• Cytokine Production
• Cell Activation
• T Cell Activation
• Cell Cycle
• Cytokine Secretion
• Sensitization
• Cell Death
• Lymphocyte Activation

• Cell Differentiation
• Inflammatory Response
• Localization
• Tolerance Induction
• Lymphocyte Proliferation
• Aging
• Hypersensitivity

PTMs

• Phosphorylation
• Demethylation
• Cleavage
• Acetylation

• Deacetylation
• Methylation
• Reduction
• Dephosphorylation

Research Areas

• Adaptive Immunity
• Apoptosis
• Cytokine Research
• Immunology
• Innate Immunity

• Mast Cell Markers
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL2RA

What Are the Best Uses of the IL2RA Marker?

What Are the Best Uses Of The IL2RA Molecular Marker? This article will help you determine if your sample has high levels of IL2RA. You can purchase the IL2RA monoclonal antibody by Boster Bio. This antibody is flow validated and APC conjugated. It reacts with Human. If you don't want your sample to be detected, you can also purchase blocking peptide.

CD25

IL2RA is a candidate biomarker for leukemia stem cells and is often expressed in AML. Its gene expression was examined in 54 primary AML BM samples using TaqMan RQ-PCR and fluorescent cell microscopy. The protein level was expressed as a proportion of leukemia blast cells and was related to the protein expression of CD25 and the Spearman correlation coefficient (r = 0.893).

The IL-2/IL-2RA pathway is essential for immune homeostasis. Increasing concentrations of sCD25 in the periphery may indicate immune activation. Additionally, a high sCD25 level may signal inflammatory disease. To date, no definitive study has established the precise mechanism of IL-2 cleavage, although sCD25 levels may be a good indicator of inflammation.

Besides determining the presence of IL2RA in liver tissue, this marker is also used to determine whether the disease is advanced or reversible. Its high levels in the liver are associated with an increased risk of fibrosis. In morbidly obese patients, IL2RA is significantly associated with hepatic fibrosis, and the presence of this marker in the liver may be useful in assessing the severity of NAFLD.

In a study of 80 patients with intermediate-risk AML, high IL2RA mRNA expression significantly predicted adverse outcomes, including shorter EFS and OS. ROC curves of nine mRNA gene expression markers were calculated to determine whether IL2RA was better than the other potential biomarkers. However, further studies are needed to verify the reliability and utility of this marker. It is important to note that high levels of IL2RA mRNA in AML patients are significantly associated with poor outcomes, but they are not sufficient to predict these outcomes.

IL-2RA

If you're interested in the best ways to test your immune system's ability to detect IL-2RA, consider using Boster Bio's anti-IL-2RA antibody. This peptide-based monoclonal antibody reacts with human IL-2Ralpha. The cost of blocking peptides varies, depending on the immunogen's length.

The IL-2RA marker has many uses in the immune system. The protein is a type I transmembrane glycoprotein found on activated B and T cells. When it interacts with another gene called CD122, it forms a heterodimer that acts as a high-affinity receptor for IL-2. The IL2R gene has been mapped to 10p15-p14. The IL2R gene is highly expressed in some disease states, and the soluble form of the IL-2R (sIL-2R) is a highly valuable tool for tracking disease progression. Boster validates all antibodies and is dedicated to providing you with the best products possible.

IL-2Rb

Boster Bio Anti-IL-2Rb Antibody is an ELISA, IHC, and WB tested antibody that reacts with Human, Mouse, and Rat IL-2 receptors. It also reacts with Human and Monkey IL-2 receptors. In addition, Boster Bio Anti-IL-2Rb has a shelf-life of six months when stored at -20°C. The antigens used to test the antibodies are synthesized from the IL-2Rb gene and are expressed in human cells.

A study of patients with IL-2Rb deficiency found that forced expression of wild-type IL-2Rb increased IL-2 response in vitro. This finding paves the way for development of IL-2-based therapies for the disease. However, these results must be interpreted with caution. Further studies are needed to confirm the results. This is an exciting time to be working in IL-2 research and development.

IL-2Rb is normally expressed on the surface of NK cells and T cells. Humans with the L77P mutation have lower levels of surface expression of IL-2Rb. Their heterozygous parent showed intermediate levels of IL-2Rb expression. In addition, patients' cells produced more IL-2Rb in the cytosol than healthy cells. In addition, human IL-2Rb deficiency has many similarities with KO mice.

The mutIL2RB plasmid showed low surface IL-2Rb expression, but high GFP co-expression. Moreover, WT IL-2Rb expressed more on the cell surface than the L77P mutant, while L77P IL-2Rb did not reach the surface of the cells. Interestingly, in the mutant L77P IL-2Rb gene, no functional IL-2Rb protein was expressed.

IL-2Rb is also known as CD122 and is a protein that encodes the beta subunit of the IL-2 receptor. It maps to 22q12.3 and contains 10 exons. Exons 2-10 encode the protein product. The IL-2 receptor exists in three affinity forms. Moreover, mutants of IL-2 receptor have different cytoplasmic domains, causing them to trigger monocyte and granulocyte differentiation signals.

IL-2Rg

The IL-2Rg gene is expressed in gastric tissues and cell lines. Using RNAiso Plus reagent, total RNA was extracted from the samples. RNA was reverse-transcribed using a PrimeScript(tm) RT reagent kit. IL2RG and GAPDH were used as internal controls. The IL-2Rg primer sequence was GTCCACCACCACTTTGT.

In a recent study, IL2RG expression was significantly higher in GC tissues than in adjacent normal gastric tissue. This association was verified using western blotting and RT-qPCR. Furthermore, IL2RG expression was correlated with poorer overall survival. Further, IL2RG was found to play a vital role in the CCRI pathway, demonstrating its role in CCRI.