Interferon beta Antibodies

Interferon beta (IFNB1)

Has antiviral, antibacterial and anticancer activities. .

Gene Information

Human
Gene Name:	IFNB1
Uniprot:	P01574
Entrez:	3456

Family

Belongs to:
alpha/beta interferon family

Alternative Names

Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Molecular Weight

Mass (kDA):
22.294 kDA

Genomic Context

Human
Location:	9p21.3
Sequence:	9; NC_000009.12 (21077104..21077942, complement)

Subcellular Localizations

Secreted.

Diseases

• Virus Diseases
• Neoplasms
• Malignant Neoplasms
• Infective Disorder
• Innate Immune Response
• Malignant Paraganglionic Neoplasm
• Newcastle Disease
• Glioma
• Carcinoma
• Melanoma
• Dysequilibrium Syndrome
• Malignant Neoplasm Of Lung

• Sting Injury
• Leukemia
• Cytogenetic Abnormality
• Tissue Adhesions
• Neoplasm Metastasis
• Endoplasmic Reticulum Stress

Pathways

• Immune Response
• Innate Immune Response
• Pathogenesis
• Cell Cycle
• Rna Interference
• Secretion
• Transport
• Transposition
• Cell Proliferation
• Electron Transport
• Electron Transport Chain
• Response To Virus
• Protein Secretion

• Virulence
• Inflammatory Response
• Methylation
• Cell Division
• Flight
• Dna Replication
• Cell Death

PTMs

• Ubiquitination
• Phosphorylation

• Isgylation
• Methylation

Research Areas

• Apoptosis
• Cancer
• Cytokine Research
• Immunology
• Innate Immunity

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IFNB1

Best Uses Of The IFNB1 Marker

If you are interested in learning more about Boster Bio IFNB1Marker, please read on. Learn about its quality and specificity, as well as its applications. Then, you'll be ready to purchase one for your research needs. Read on to find out more about Boster Bio and how it can benefit your research. You'll also be able to get more information on BeNeLux deliveries and custom services.

Boster Bio IFNB1 Marker

In order to maximize the utility of your IFNB1 marker, it's essential to know how to properly use it. Boster Bio offers many flow methods. Follow the steps below to find the perfect reagent for your experiment. Once you've got a sample ready to use, follow the instructions on the reagent's label for proper storage and handling. If you don't understand the flow process, we have guides and tips to help you use Boster Bio IFNB1Marker.

Applications

The IFNB1 indicator can be used not only for the diagnosis of autoimmune disease but also to study the innate immune system. One study used d2eGFP tagged THP1IBER cells to transfect with dsDNA labelled with Texas red to detect IFNB1 protein expression in individual cells. It is easy to detect in single cells because d2eGFP, a fluorescent protein can be detected.

The IFNB1 mark is a member from the alpha/betainterferon family. It is highly expressed in skin. It has antiviral, antibacterial, and anticancer activities. This gene is a candidate for immunotherapy. It is also used frequently to detect inflammatory bowel diseases. However, it has been linked with other diseases. Researchers are working towards this goal, even though it isn't yet possible to identify a patient with the specific disease.

Genomic DNA was extracted using a NaCl/EtOH precipitation process and quantified using WPRE sequence in lentiviral vector. The copy number of the albumin genes in the corresponding cell lines was used to calculate the number of cells. The standard curves for transgene cassette copy number were derived from pCCL/IFNB1-d2eGFP-3'UTR and pAlbumin, which were gifts from Didier Trono.

Quality

Sanbio has the IFNB1 anti antibody, a powerful tool for studying IFNB1 expression within cancer cells. Boster Bio provides ELISA kits designed for IHC and picogram sensitive ELISAs. Their extensive range includes more that 12,000 antibodies, all of which are approved for use in IHC, WB, Flow, and other applications. Each antibody is quantitatively tested against untransfected cell line and recombinant proteins to ensure its specificity.

Specificity

Human interferon-beta inhibits growth of MCF-7 breast cancer xenografts. The study used the human transient expression system to determine the influence of IFN-alpha 1 and IFN-beta promoters on mRNA levels of the target. IFNB1 has been found in breast cancer cells as well normal cells. The antigen was immobilized on the surfaces of 93VU147T cell cells for this study.

The IFNB1 gene may be a useful indicator of the best COVID-19 treatment for patients suffering from COV. A subset (or subset) of human fibroblasts can express IFNB1. This subset cells are highly susceptible to infection. Low levels of IFNB1 are associated with lower infection risks in this population. It may also help predict how COVID-19 treatment will turn out.

IFNb is induced in human cells by infection with an IFN-stimulated response element. The IFNB1 markers recognize this element by binding to the IFN-stimulated return element PRDI. The IFNB1 marker is highly specific and discriminative for detecting HNSCC with HPV. This gene is highly prevalent in HNSCC and is linked to more than 90% of cases. The E7 protein encoded by HPV16 and IFNB1 shares low homology with ISGF3. The mechanism by which the viruses inhibit the IFN-1I system is not known.

The IFNB1 gene is involved in a signaling pathway that initiates a cytotoxic T cell response. It is crucial for understanding how the immune system recognizes harmful signals. Although it does not recognize DNA short, the IFNB1 gene marker is co-expressed with cGAS. The IFN receptor feedback pathway may also occur downstream to TBK1 phosphorylation.

Cost

The IFNB1 gene is a central regulator of fibroblast growth. Ifnb1/ mice have a reduced rate of fibroblast growth upregulation compared with control animals. This is the most common condition, but it does not necessarily cause fibrosis. The IFNB1 gene can be used to diagnose certain cancers. The cost for the IFNB1 gene marker depends on which type of test is used and how many genes are used.