ITPR1 Antibodies

AND ITPR1 ELISA kits, ITPR1 Proteins

Many biological assays use antibodies to detect ITPR1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ITPR1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ITPR1 antibodies...

We validate the specificity of these antibodies to ITPR1 by testing them on tissues known to express ITPR1 positively and negatively. Browse below to find the ITPR1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ITPR1 Infographic by Boster Bio

All ITPR1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-IP3 receptor/ITPR1 Antibody Picoband®

3 Citations 1 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9225
100 μg/vial

Anti-Phospho-IP3R-I (S1764) ITPR1 Antibody

Human, Mouse, Rat

ELISA, IHC-P, WB

$380
Cat # A01465S1764
100ul

Anti-Phospho-IP3R-I (S1598) ITPR1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC

$380
Cat # A01465S1598
100ul

Anti-IP3 Receptor Rabbit Monoclonal Antibody

Human, Mouse, Rat

IP, IHC, WB

$370
Cat # M01465-1
100 μl/vial

ITPR1 Overview

Facts about Inositol 1,4,5-trisphosphate receptor type 1.

Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)

Intracellular channel that mediates calcium release from the endoplasmic reticulum after stimulation by inositol 1,4,5- trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity).

Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Gene Information

Human
Gene Name:	ITPR1
Uniprot:	Q14643
Entrez:	3708

Family

Belongs to:

InsP3 receptor family

Alternative Names

DKFZp313E1334; DKFZp313N1434; inositol 14,5-triphosphate receptor, type 1; inositol 14,5-trisphosphate receptor type 1; INSP3R1; IP3 receptor isoform 1; IP3 receptor; IP3R 1; IP3R; IP3R1; SCA15; SCA16; spinocerebellar ataxia 15; spinocerebellar ataxia 16; Type 1 inositol 14,5-trisphosphate receptor; Type 1 InsP3 receptor

Molecular Weight

Mass (kDA):
313.929 kDA

Genomic Context


Human

Location:	3p26.1
Sequence:	3; NC_000003.12 (4493348..4847840)

Tissue Specificity

Widely expressed.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum and secretory granules (By similarity).

Diseases

Neuroblastoma
Ataxia
Ataxia, Spinocerebellar
Cerebellar Ataxia
Alzheimer's Disease
Nervousness
Neurodegenerative Disorders
Malignant Neoplasms
Atrophy
Nerve Degeneration
Carcinoma
Neoplasms

Diabetes Mellitus
Leukemia
Hypertrophy
Pertussis
Acute Promyelocytic Leukemia
Malignant Paraganglionic Neoplasm
Depressive Disorder

Interacting Proteins

AKT1
VDAC1

Pathways

Localization
Secretion
Cell Death
Fertilization
Transport
Exocytosis
Pathogenesis
Cell Activation
Oocyte Maturation
Sensitization
Proteolysis
Cell Cycle
T Cell Activation

Cell Differentiation
Programmed Cell Death
Store-operated Calcium Entry
Rna Interference
Reverse Transcription
Metaphase
Platelet Activation

PTMs

Phosphorylation
Dephosphorylation
Cleavage
Ubiquitination
Methylation
Nitration

Biotinylation
Formylation
Phosphorothioation
Reduction
Oxidation
Palmitoylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITPR1

References

PMID: 7945203 by Yamada N., et al. Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization.

PMID: 7852357 by Harnick D.J., et al. The human type 1 inositol 1,4,5-trisphosphate receptor from T lymphocytes. Structure, localization, and tyrosine phosphorylation.

3 Publications of Boster ITPR1 Antibodies & ELISA Kits

PubMed ID: 10.1155/2021/8493431, LncRNA LINC00662 Exerts an Oncogenic Effect on Osteosarcoma by the miR-16-5p/ITP...
PubMed ID: 33203874, Ma WQ,Sun XJ,Zhu Y,Liu NF. PDK4 promotes vascular calcification by interfering w...
PubMed ID: 23437066, Neuroprotective Effect of Kaempferol Glycosides against Brain Injury and Neuroin...

*More publications can be found for each product on its corresponding product page