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Integrin beta-1 Antibodies
AND ITGB1 ELISA kits, Integrin beta-1 Proteins
Many biological assays use antibodies to detect Integrin beta-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin beta-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin beta-1 antibodies...
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ITGB1 Infographic by Boster Bio
All ITGB1 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin beta 1/ITGB1 Antibody Picoband®
10 Citations 1 Q&As
Human, Rat
IHC, WB
$370
Cat # PB9086
100 μg/vial
Cat # PB9086
100 μg/vial
Anti-Integrin beta 1 ITGB1 Rabbit Monoclonal Antibody
3 Citations 7 Q&As
Human
IHC, WB
$370
Cat # M00772-2
100 μl
Cat # M00772-2
100 μl
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M00772
100 μl
Cat # M00772
100 μl
Human, Mouse, Rat
IHC, WB
$370
Cat # M00772-1
100 μl
Cat # M00772-1
100 μl
Human
IHC, WB
$431
Cat # M00772-3
100uL
Cat # M00772-3
100uL
Human, Mouse, Rat
ELISA
$480
Cat # EKC1303
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1303
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2047
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2047
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2075
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2075
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2639
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2639
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA, IHC, WB
$380
Cat # A00772T788
100ul
Cat # A00772T788
100ul
Human, Mouse, Rat
ELISA, WB
$380
Cat # A00772Y795
100ul
Cat # A00772Y795
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A00772T789
100ul
Cat # A00772T789
100ul
Human, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M00772-4
100 µl
Cat # M00772-4
100 µl
ITGB1 Overview
Facts about Integrin beta-1.
Integrin beta-1 (ITGB1)
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domain names within the alternatively spliced CS-1 and CS-5 regions of fibronectin.
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGB1 |
| Uniprot: | P05556 |
| Entrez: | 3688 |
Family
| Belongs to: |
|---|
| integrin beta chain family |
Alternative Names
CD29 antigen; CD29; Fibronectin receptor subunit beta; FNRBVLAB; GPIIA; Integrin beta 1; integrin beta-1; integrin VLA-4 beta subunit; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includesMDF2, MSK12); ITGB1; MDF2; MSK12; very late activation protein, beta polypeptide; VLA-4 subunit beta; VLA-BETA
Molecular Weight
Mass (kDA):
88.415 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p11.22 |
| Sequence: | 10; NC_000010.11 (32900318..32958230, complement) |
Tissue Specificity
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non- proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane; Single-pass type I membrane protein. Recycling endosome. Melanosome. Cleavage furrow. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, focal adhesion. Cell surface. Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a f
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Tumor Angiogenesis
- Neoplasm Metastasis
- Leukemia
- Carcinoma
- Acute Promyelocytic Leukemia
- Malignant Paraganglionic Neoplasm
- Neoplasm Invasiveness
- Adenocarcinoma
- Fibrosis
Interacting Proteins
- ADAM17
- ANGPTL4
- CRKL
- CSF2RB
- CX3CL1
- ENG
- FABP3
- FLNA
- ITGA2
- ITGA4
Pathways
- Cell Adhesion
- Pathogenesis
- Angiogenesis
- Cell Proliferation
- Cell Migration
- Immune Response
- Cell Death
- Fertilization
- Blastocyst Formation
- Localization
- Cell Division
- Cell Differentiation
- Cell-matrix Adhesion
PTMs
- Phosphorylation
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Cytokine Research
- Immunology
- Mesenchymal Stem Cell Markers
- Neuronal Cell Markers
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGB1
bosterbio.com/bosterbio-gene-info-cards/ITGB1
References
PMID: 2958481 by Argraves W.S., et al. Amino acid sequence of the human fibronectin receptor.
PMID: 7681433 by Balzac F., et al. Expression and functional analysis of a cytoplasmic domain variant of the beta 1 integrin subunit.
10 Publications of Boster Integrin beta-1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/ol.2016.4234, Inhibition of the peritoneal metastasis of human gastric cancer cells by dextran...
- PubMed ID: 10.3892/mmr.2015.4449, Suppression of A549 cell proliferation and metastasis by calycosin via inhibitio...
- PubMed ID: 10.3892/ijmm.2016.2519, Abnormalities in the basement membrane structure promote basal keratinocytes in ...
- PubMed ID: 10.1002/jso.21613, Mechanical stiffness of liver tissues in relation to integrin β1 expression may...
- PubMed ID: 26986690, Abnormalities in the basement membrane structure promote basal keratinocytes in ...
- PubMed ID: 26956998, Suppression of A549 cell proliferation and metastasis by calycosin via inhibitio...
- PubMed ID: 26807166, Effects of human umbilical cord mesenchymal stem cell transplantation combined w...
- PubMed ID: 26616638, Isolation and morphological characterization of ovine amniotic fluid mesenchymal...
- PubMed ID: 22211239, Yin D, Tian L, Ye Y, Li K, Wang J, Cheng P, Chen A, Guo F, Huang H. Int J Mol Me...
- PubMed ID: 24465646, Lin H, Yang Y, Wang Y, Wang L, Zhou X, Liu J, Peng D. Plos One. 2014 Jan 21;9(1)...
*More publications can be found for each product on its corresponding product page