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Integrin alpha-7 Antibodies
AND ITGA7 ELISA kits, Integrin alpha-7 Proteins
Many biological assays use antibodies to detect Integrin alpha-7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-7 antibodies...
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ITGA7 Infographic by Boster Bio
All ITGA7 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin alpha-7 ITGA7 Antibody Picoband®
1 Citations 1 Q&As
Human, Mouse, Rat
WB
$370
Cat # PA2226
100 μg/vial
Cat # PA2226
100 μg/vial
ITGA7 Overview
Facts about Integrin alpha-7.
Integrin alpha-7 (ITGA7)
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and ease their localization in laminin-rich websites of secondary fiber formation.
It's involved in the upkeep of the myofibers cytoarchitecture in addition to for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro).
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA7 |
| Uniprot: | Q13683 |
| Entrez: | 3679 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
FLJ25220; integrin alpha 7 chain; Integrin alpha 7; integrin alpha-7; integrin, alpha 7; ITGA7
Molecular Weight
Mass (kDA):
128.948 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.2 |
| Sequence: | 12; NC_000012.12 (55684568..55716037, complement) |
Tissue Specificity
Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Muscular Dystrophy
- Dystrophy
- Congenital Muscular Dystrophy (disorder)
- Carcinoma
- Myopathy
- Coronary Microvascular Disease
- Tissue Adhesions
- Neoplasm Metastasis
- Leiomyosarcoma
- Congenital Myopathy (disorder)
Pathways
- Cell Growth
- Localization
- Cell Motility
- Cell Adhesion
- Tissue Development
- Dna Replication
- Induction Of Apoptosis
- Cell Death
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA7
bosterbio.com/bosterbio-gene-info-cards/ITGA7
References
PMID: 9473524 by Leung E., et al. A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing.
PMID: 9590299 by Hayashi Y.K., et al. Mutations in the integrin alpha7 gene cause congenital myopathy.
1 Publications of Boster Integrin alpha-7 Antibodies & ELISA Kits
- PubMed ID: 25887589, Zhang H, Teng X, Liu Z, Zhang L, Liu Z. J Exp Clin Cancer Res. 2015 Feb 12;34:16...
*More publications can be found for each product on its corresponding product page