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Integrin alpha-3 Antibodies
AND ITGA3 ELISA kits, Integrin alpha-3 Proteins
Many biological assays use antibodies to detect Integrin alpha-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-3 antibodies...
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ITGA3 Infographic by Boster Bio
All ITGA3 Products
Product
Figures
Specificity
Applications
Price
Anti-Integrin alpha 3/ITGA3 Antibody Picoband®
1 Citations 1 Q&As
Human, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA1621
100 μg/vial
Cat # PA1621
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, IHC-F, ICC, WB
$370
Cat # A02902
100 μg/vial
Cat # A02902
100 μg/vial
Human
Flow Cytometry, IP, IHC-F, WB
$299
Cat # M02902
0.1 mg
Cat # M02902
0.1 mg
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02902-1
100 μg/vial
Cat # A02902-1
100 μg/vial
ITGA3 Overview
Facts about Integrin alpha-3.
Integrin alpha-3 (ITGA3)
Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes at a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
Alpha- 3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. .
Gene Information
| Human | |
|---|---|
| Gene Name: | ITGA3 |
| Uniprot: | P26006 |
| Entrez: | 3675 |
Family
| Belongs to: |
|---|
| integrin alpha chain family |
Alternative Names
antigen identified by monoclonal J143; CD49 antigen-like family member C; CD49c antigen; CD49c; FLJ34631; FLJ34704; FRP-2; Galactoprotein B3; GAP-B3; GAPB3CD49C; Integrin alpha 3; integrin alpha-3; integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor); ITGA3; MSK18; VCA-2; very late activation protein 3 receptor, alpha-3 subunit; VL3A; VLA-3 subunit alpha; VLA3a
Molecular Weight
Mass (kDA):
116.612 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50056065..50090481) |
Tissue Specificity
Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell projection, invadopodium membrane; Single-pass type I membrane protein. Cell projection, filopodium membrane; Single-pass type I membrane protein. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner.
Diseases
- Malignant Neoplasms
- Neoplasms
- Neoplasm Metastasis
- Tissue Adhesions
- Carcinoma
- Malignant Squamous Cell Neoplasm
- Cell Invasion
- Cell Transformation, Neoplastic
- Adenocarcinoma
- Nephrotic Syndrome
- Stomach Neoplasms
- Metastatic Malignant Neoplasm To The Lymph Node
Interacting Proteins
- CD151
Pathways
- Cell Proliferation
- Cell Adhesion
- Regulation Of Biological Process
- Reproductive Process
- Skin Development
- Inner Ear Development
- Embryo Development
- Blastocyst Formation
- Axon Guidance
- Cell Cycle
- Multicellular Organismal Process
- Wound Healing
- Cell-cell Adhesion
PTMs
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA3
bosterbio.com/bosterbio-gene-info-cards/ITGA3
References
PMID: 1655803 by Takada Y., et al. Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.
PMID: 1714443 by Tsuji T., et al. Identification of human galactoprotein b3, an oncogenic transformation-induced membrane glycoprotein, as VLA-3 alpha subunit: the primary structure of human integrin alpha 3.
1 Publications of Boster Integrin alpha-3 Antibodies & ELISA Kits
- PubMed ID: 32544337, Li H,Yuan L,Long Y,Fang H,Li M,Liu Q,Xia X,Qin C,Zhang Y,Lan X,Gai Y.Synthesis a...
*More publications can be found for each product on its corresponding product page