Integrin alpha-2 Antibodies

AND ITGA2 ELISA kits, Integrin alpha-2 Proteins

Many biological assays use antibodies to detect Integrin alpha-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Integrin alpha-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Integrin alpha-2 antibodies...

We validate the specificity of these antibodies to Integrin alpha-2 by testing them on tissues known to express ITGA2 positively and negatively. Browse below to find the ITGA2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ITGA2 Infographic by Boster Bio

All ITGA2 Products

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Specificity

Applications

Price

Anti-Integrin alpha2 ITGA2 Antibody

Human, Mouse, Rat

IHC, WB

$399
Cat # A01933
100μl

Anti-Integrin alpha 2 ITGA2 Rabbit Monoclonal Antibody

5 Q&As

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$370
Cat # M01933
100 μl

Anti-Integrin Alpha 2 ITGA2 Antibody

Human, Mouse, Rat

Flow Cytometry, IP, IF, IHC, ICC, WB

$405
Cat # A01933-1
100ul

Anti-Integrin alpha 2/ITGA2 Antibody Picoband®

Human

ELISA, Flow Cytometry, WB

$370
Cat # A01933-2
100 μg/vial

ITGA2 Overview

Facts about Integrin alpha-2.

ITGA2 3D structure. Source: alphafold

Integrin alpha-2 (ITGA2)

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It admits the proline-hydroxylated sequence G-F-P-G-E-R in hydration.

It's responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. .

Gene Information

Human
Gene Name:	ITGA2
Uniprot:	P17301
Entrez:	3673

Family

Belongs to:

integrin alpha chain family

Alternative Names

alpha-2 subunit; CD49b antigen; CD49b; Integrin alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); ITGA2; VLA 2; VLA-2 alpha

Molecular Weight

Mass (kDA):
129.295 kDA

Genomic Context


Human

Location:	5q11.2
Sequence:	5; NC_000005.10 (52989352..53094779)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.

Diseases

Tissue Adhesions
Malignant Neoplasms
Cerebrovascular Accident
Neoplasms
Diabetes Mellitus
Neoplasm Metastasis
Ischemic Stroke
Hemorrhage
Thrombosis
Carcinoma
5,10-methylenetetrahydrofolate Reductase Deficiency
Diabetes Mellitus, Non-insulin-dependent
Inflammation

Von Willebrand Disease
Variable Number Tandem Repeat
Cardiovascular Diseases
Hypertensive Disease
Diabetic Retinopathy
Infarction
Myocardial Infarction

Interacting Proteins

Ap2m1
ITGB1
KDR
Rab21
SHARPIN

Pathways

Pathogenesis
Cell Adhesion
Hemostasis
Coagulation
Immune Response
Platelet Aggregation
Inflammatory Response
Localization
Cell Growth
Osteoblast Differentiation
Fibroblast Proliferation
Lymphangiogenesis
Mrna Splicing

Cell Motility
Cell Cycle
Cell Differentiation
Cell Proliferation
Tissue Morphogenesis
Metaphase
Megakaryocyte Differentiation

PTMs

Demethylation

Phosphorylation

Methylation

Research Areas

Cellular Markers
Innate Immunity
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ITGA2

References

PMID: 2545729 by Takada Y., et al. The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

PMID: 8276836 by Zutter M.M., et al. The human alpha 2 integrin gene promoter. Identification of positive and negative regulatory elements important for cell-type and developmentally restricted gene expression.