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ISL1 Antibodies
AND ISL1 ELISA kits, ISL1 Proteins
Many biological assays use antibodies to detect ISL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ISL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ISL1 antibodies...
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ISL1 Infographic by Boster Bio
All ISL1 Products
Product
Figures
Specificity
Applications
Price
Anti-Islet1 Monoclonal Antibody
16 Q&As
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02969-1
100 μl
Cat # M02969-1
100 μl
Human, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A02969-3
100 µg/vial
Cat # A02969-3
100 µg/vial
ISL1 Overview
Facts about Insulin gene enhancer protein ISL-1.
Insulin gene enhancer protein ISL-1 (ISL1)
Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory system essential for retinal ganglion cell (RGC) differentiation.
Cooperates with the transcription factor POU4F2 to reach maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1.
Gene Information
| Human | |
|---|---|
| Gene Name: | ISL1 |
| Uniprot: | P61371 |
| Entrez: | 3670 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
insulin gene enhancer protein ISL-1; ISL LIM homeobox 1; ISL1 transcription factor, LIM/homeodomain; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1; Isl-1; Islet1; Islet-1
Molecular Weight
Mass (kDA):
39.036 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q11.1 |
| Sequence: | 5; NC_000005.10 (51383448..51394730) |
Tissue Specificity
Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.
Subcellular Localizations
Nucleus.
Diseases
- Diabetes Mellitus
- Congenital Heart Defects
- Nervousness
- Heart Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Neoplasms
- Pituitary Diseases
- Hypoplasia
- Malignant Neoplasms
- Congenital Abnormality
- Tissue Adhesions
- Carcinoma
- Pancreatic Neoplasm
Interacting Proteins
- ZNF511
Pathways
- Cell Differentiation
- Heart Development
- Neurogenesis
- Secretion
- Regeneration
- Pathogenesis
- Cell Cycle
- Cell Development
- Pancreas Development
- Neuron Differentiation
- Cell Adhesion
- Heart Formation
- Insulin Secretion
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ISL1
bosterbio.com/bosterbio-gene-info-cards/ISL1
References
PMID: 7907017 by Wang M., et al. The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage.
PMID: 7912209 by Tanizawa Y., et al. Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism.