IRX5 Antibodies

AND IRX5 ELISA kits, IRX5 Proteins

Many biological assays use antibodies to detect IRX5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRX5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRX5 antibodies...

We validate the specificity of these antibodies to IRX5 by testing them on tissues known to express IRX5 positively and negatively. Browse below to find the IRX5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IRX5 Infographic by Boster Bio

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IRX5 (NM_005853) Human Over-expression Lysate

Human

$960
Cat # LS010265
100 µg

IRX5 Overview

Facts about Iroquois-class homeodomain protein IRX-5.

IRX5 3D structure. Source: alphafold

Iroquois-class homeodomain protein IRX-5 (IRX5)

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation.

May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of the cell cycle and apoptosis in prostate cancer cells.

Gene Information

Human
Gene Name:	IRX5
Uniprot:	P78411
Entrez:	10265

Family

Belongs to:

TALE/IRO homeobox family

Alternative Names

Homeodomain protein IRX-2A; Homeodomain protein IRXB2; iroquois homeobox 5; Iroquois homeobox protein 5; iroquois-class homeodomain protein IRX-5; IRX2A; IRX-2a; IRXB2

Molecular Weight

Mass (kDA):
50.361 kDA

Genomic Context


Human

Location:	16q12.2
Sequence:	16; NC_000016.10 (54930865..54934485)

Subcellular Localizations

Nucleus.

Diseases

Nervousness
Cardiac Arrhythmia
Endocardial Cushion Defects
Neoplasms
Syndactyly Of Toes With Fusion Of Bones
Childhood Renal Neoplasm
Malignant Neoplasm Of Breast
Craniofacial Abnormalities
Colonic Neoplasms
Malignant Tumor Of Colon
Cardiac Hypertrophy
Kidney Neoplasm
Insulin Resistance

Congenital Heart Defects
Malignant Neoplasms
Mammary Neoplasms
Anaplasia
Congenital Diaphragmatic Hernia
Plant Diseases
Brugada Syndrome (disorder)

Pathways

Regionalization
Cell Cycle
Lung Development
Lung Morphogenesis
Neural Tube Closure
Cell Migration
Neurogenesis
Regulation Of Gene Expression
Cardiac Conduction
Spermatogenesis
Cell Maturation
Tissue Development
Cell Differentiation

Cell Communication
Gonad Development
Gastrulation
Cell Development
Somitogenesis
Bmp Signaling Pathway
Disease Resistance

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRX5

References

PMID: 10370142 by Lewis M.T., et al. Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast.

PMID: 18519790 by Myrthue A., et al. The iroquois homeobox gene 5 is regulated by 1,25-dihydroxyvitamin D3 in human prostate cancer and regulates apoptosis and the cell cycle in LNCaP prostate cancer cells.