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Irx3 Antibodies
AND Irx3 ELISA kits, Irx3 Proteins
Many biological assays use antibodies to detect Irx3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Irx3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Irx3 antibodies...
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Irx3 Overview
Facts about Iroquois-class homeodomain protein IRX-3.
Iroquois-class homeodomain protein IRX-3 (Irx3)
Transcription element. Involved in SHH-dependent neural patterning.
Together with NKX2-2 and NKX6-1 functions to restrict the generation of motor neurons into the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor variables, which can be repressed by SHH signals.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Irx3 |
| Uniprot: | P81067 |
| Entrez: | 16373 |
Family
| Belongs to: |
|---|
| TALE/IRO homeobox family |
Alternative Names
Homeodomain protein IRXB1; iroquois homeobox 3; Iroquois homeobox protein 3; iroquois-class homeodomain protein IRX-1; iroquois-class homeodomain protein IRX-3; IRX-1; IRXB1FLJ99187
Molecular Weight
Mass (kDA):
52.693 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 8 C5|8 44.55 cM |
| Sequence: | 8; |
Tissue Specificity
Expressed by neural progenitor cells in discrete domains of the ventral neural tube. Also expressed in specific and overlapping patterns with Irx1 and Irx2 in the developing and adult metanephric kidney. In the adult metanephros, renal expression is confined to the S3 segment of the proximal tubule, in the loop of Henle.
Diseases
- Neoplasms
- Malignant Neoplasms
- Nervousness
- Refractive Errors
- Comatose
- Syndactyly Of Toes With Fusion Of Bones
- Malignant Neoplasm Of Breast
- Carcinoma
- Anaplasia
- Cell Transformation, Neoplastic
- Tissue Adhesions
- Endocardial Cushion Defects
Pathways
- Regionalization
- Cell Proliferation
- Dna Methylation
- Methylation
- Cell Adhesion
- Neural Tube Closure
- Sex Determination
- Spinal Cord Development
- Tube Closure
- Neurogenesis
- Cell Cycle
- Gastrulation
- Cell Migration
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Irx3
bosterbio.com/bosterbio-gene-info-cards/Irx3
References
PMID: 9486539 by Bosse A., et al. Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system.
PMID: 10926765 by Christoffels V.M., et al. Patterning the embryonic heart: identification of five mouse Iroquois homeobox genes in the developing heart.