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IRAK4 Antibodies
AND IRAK4 ELISA kits, IRAK4 Proteins
Many biological assays use antibodies to detect IRAK4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRAK4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRAK4 antibodies...
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IRAK4 Infographic by Boster Bio
All IRAK4 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse
ELISA, Flow Cytometry, IHC, WB
$380
Cat # M01247-1
100ul
Cat # M01247-1
100ul
IRAK4 Overview
Facts about Interleukin-1 receptor-associated kinase 4.
Interleukin-1 receptor-associated kinase 4 (IRAK4)
Serine/threonine-protein kinase that plays a critical role in initiating innate immune reaction against foreign pathogens. Is rapidly recruited by MYD88 into the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2.
Phosphorylates originally IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino- mediated polyubiquitination of IRAK1.
Gene Information
| Human | |
|---|---|
| Gene Name: | IRAK4 |
| Uniprot: | Q9NWZ3 |
| Entrez: | 51135 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; EC 2.7.11.1; interleukin-1 receptor-associated kinase 4; IPD1; IRAK4; IRAK-4; NY-REN-64; REN64; Renal carcinoma antigen NY-REN-64
Molecular Weight
Mass (kDA):
51.53 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q12 |
| Sequence: | 12; NC_000012.12 (43758909..43789543) |
Subcellular Localizations
Cytoplasm.
Diseases
- Inflammation
- Infective Disorder
- Immunologic Deficiency Syndromes
- Innate Immune Response
- Bacterial Infections
- Inflammatory Response
- Malignant Neoplasms
- Systemic Infection
- Communicable Diseases
- Arthritis
- Ectodermal Dysplasia
- Autoimmune Reaction
- Dysplasia
Interacting Proteins
- IRAK2
- Irak3
- MYD88
- PELI1
- PELI2
- TIRAP
Pathways
- Inflammatory Response
- Cytokine Production
- Immune Response
- Innate Immune Response
- Pathogenesis
- Secretion
- Cell Activation
- Cell Proliferation
- Protein Phosphorylation
- Response To Lipopolysaccharide
- Translation
- Phagocytosis
- Rna Interference
PTMs
- Phosphorylation
- Ubiquitination
- Cleavage
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRAK4
bosterbio.com/bosterbio-gene-info-cards/IRAK4
References
PMID: 11960013 by Li S., et al. IRAK4: a novel member of the IRAK family with the properties of an IRAK-kinase.
PMID: 12496252 by Jiang Z., et al. Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.