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- Table of Contents
Facts about IQ motif and SEC7 domain-containing protein 1.
Accelerates GTP binding by ARFs of all three classes. Guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin.
Human | |
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Gene Name: | IQSEC1 |
Uniprot: | Q6DN90 |
Entrez: | 9922 |
Belongs to: |
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BRAG family |
ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; BRAG2; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; KIAA0763Brefeldin-resistant Arf-GEF 2 protein
Mass (kDA):
108.314 kDA
Human | |
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Location: | 3p25.2-p25.1 |
Sequence: | 3; NC_000003.12 (12897043..13283257, complement) |
Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis.
Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic.
PMID: 16461286 by Dunphy J.L., et al. The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins.
PMID: 11226253 by Someya A., et al. ARF-GEP(100), a guanine nucleotide-exchange protein for ADP- ribosylation factor 6.