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- Table of Contents
Facts about Inversin.
Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests it is needed in renal growth to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling (By similarity).
Mouse | |
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Gene Name: | Invs |
Uniprot: | O89019 |
Entrez: | 16348 |
Belongs to: |
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No superfamily |
Inversin
Mass (kDA):
117.129 kDA
Mouse | |
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Location: | 4 B1|4 26.11 cM |
Sequence: | 4; |
Strongly expressed in the primary cilia of renal cells, especially in the varicosities, swellings observed in the cilia. Localizes in the node monocilia and in other 9+0 monocilia, including those of kidney epithelial cells and the pituitary gland, but it does not localize to 9+2 cilia (at protein level). In adult, it is expressed at high level in liver and kidney. Weakly or not expressed in other tissues.
PMID: 9744276 by Mochizuki T., et al. Cloning of inv, a gene that controls left/right asymmetry and kidney development.
PMID: 9771707 by Morgan D., et al. Inversin, a novel gene in the vertebrate left-right axis pathway, is partially deleted in the inv mouse.