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INPPL1 Antibodies
AND INPPL1 ELISA kits, INPPL1 Proteins
Many biological assays use antibodies to detect INPPL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INPPL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INPPL1 antibodies...
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INPPL1 Infographic by Boster Bio
All INPPL1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01790
100 μg/vial
Cat # A01790
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01790
100 μg/vial
Cat # M01790
100 μg/vial
INPPL1 Overview
Facts about Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2.
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to generate PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear.
While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence doesn't affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity.
Gene Information
| Human | |
|---|---|
| Gene Name: | INPPL1 |
| Uniprot: | O15357 |
| Entrez: | 3636 |
Family
| Belongs to: |
|---|
| inositol 1,4,5-trisphosphate 5-phosphatase family |
Alternative Names
EC 3.1.3; EC 3.1.3.n1; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL1; INPPL-1; phosphatidylinositol-34,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP2; SHIP-2; SHIP251C protein
Molecular Weight
Mass (kDA):
138.599 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q13.4 |
| Sequence: | 11; NC_000011.10 (72223861..72239147) |
Tissue Specificity
Widely expressed, most prominently in skeletal muscle, heart and brain. Present in platelets. Expressed in transformed myeloid cells and in primary macrophages, but not in peripheral blood monocytes.
Subcellular Localizations
Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, lamellipodium. Nucleus. Nucleus speckle. Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cyt
Diseases
- Diabetes Mellitus
- Neoplasms
- Diabetes Mellitus, Non-insulin-dependent
- Leukemia
- Tissue Adhesions
- Insulin Resistance
- Malignant Neoplasms
- Insulin Sensitivity
- Obesity
- Myeloid Leukemia
- Autoimmunity
- Inflammation
- Myeloid Leukemia, Chronic
Interacting Proteins
- AR
- BCAR1
- EPHA2
- GAB1
- HID1
- MET
- SORBS1
Pathways
- Cell Activation
- Localization
- Cell Proliferation
- Cell Growth
- Pathogenesis
- Mast Cell Degranulation
- Mast Cell Activation
- Cell Cycle
- Secretion
- Cell Adhesion
- Cytokine Production
- Cell Death
- Cell Migration
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
Research Areas
- Immune System Diseases
- Immunology
- Innate Immunity
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INPPL1
bosterbio.com/bosterbio-gene-info-cards/INPPL1
References
PMID: 8530088 by Hejna J.A., et al. Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.
PMID: 9367831 by Pesesse X., et al. Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.