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INPP5D Antibodies
AND INPP5D ELISA kits, INPP5D Proteins
Many biological assays use antibodies to detect INPP5D, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with INPP5D in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop INPP5D antibodies...
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INPP5D Infographic by Boster Bio
All INPP5D Products
Product
Figures
Specificity
Applications
Price
Human
IP, IF, ICC, WB
$370
Cat # P03358-1
100 μl
Cat # P03358-1
100 μl
Human
Flow Cytometry, IP, IHC, WB
$370
Cat # M03358
100 μl
Cat # M03358
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1520
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1520
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2179
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2179
1 kit, containing two 96-well plates and all necessary reagents
INPP5D Overview
Facts about Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1.
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (INPP5D)
Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling.
Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from triggering immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells.
Gene Information
| Human | |
|---|---|
| Gene Name: | INPP5D |
| Uniprot: | Q92835 |
| Entrez: | 3635 |
Family
| Belongs to: |
|---|
| inositol 1,4,5-trisphosphate 5-phosphatase family |
Alternative Names
145kD; EC 3.1.3; hp51CNMGC142142; Inositol polyphosphate-5-phosphatase of 145 kDa; inositol polyphosphate-5-phosphatase, 145kDa; INPP5D; MGC104855; SHIP; SHIPMGC142140
Molecular Weight
Mass (kDA):
133.292 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (233060342..233207903) |
Tissue Specificity
Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. Levels vary considerably within this compartment. Present in at least 74% of immature CD34+ cells, whereas within the more mature population of CD33+ cells, it is present in only 10% of cells. Present in the majority of T-cells, while it is present in a minority of B-cells (at protein level).
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Membrane raft. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Translocates from the cytoplasm to membrane ruffles in a FCGR3/CD16-dependent manner. Colocalizes with FC-gamma-RIIB receptor (FCGR2B) or FCGR3/CD16 at membrane ruffles. Tyrosine phosphorylation may also participate in membrane localization.
Diseases
- Malignant Neoplasms
- Neoplasms
- Virus Diseases
- Hepatitis, Chronic
- Embryonal Carcinoma
- Classical Hodgkin's Lymphoma
- Hepatitis C, Chronic
- Neoplasms, Germ Cell And Embryonal
- Carcinoma
- Leukemia, Myelocytic, Acute
- Fibrosis
- Myeloid Leukemia
- Infection By Trichuris Trichiura
Interacting Proteins
- CD244
- FCGR2B
- KHDRBS3
- KRT31
- KRT40
- KRTAP10-7
- KRTAP10-9
- NOTCH2NL
- SH3KBP1
Pathways
- Hypersensitivity
- Regulation Of Gene Expression
- Pathogenesis
- Localization
- Chromatin Remodeling
PTMs
Research Areas
- Adaptive Immunity
- Immunology
- Phospho-Specific
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INPP5D
bosterbio.com/bosterbio-gene-info-cards/INPP5D
References
PMID: 8769125 by Drayer A.L., et al. Cloning and expression of a human placenta inositol 1,3,4,5- tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5- phosphatase.
PMID: 8874179 by Ware M.D., et al. Cloning and characterization of human SHIP, the 145-kD inositol 5- phosphatase that associates with SHC after cytokine stimulation.