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- Table of Contents
Facts about Inhibin alpha chain.
Inhibins appear to oppose the functions of activins. .
Human | |
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Gene Name: | INHA |
Uniprot: | P05111 |
Entrez: | 3623 |
Belongs to: |
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TGF-beta family |
A-inhibin subunit; INHA; Inhibin A; inhibin alpha chain; inhibin, alpha
Mass (kDA):
39.67 kDA
Human | |
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Location: | 2q35 |
Sequence: | 2; NC_000002.12 (219572310..219575711) |
Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.
Secreted.
PMID: 3016724 by Mayo K.E., et al. Inhibin A-subunit cDNAs from porcine ovary and human placenta.
PMID: 3758355 by Stewart A.G., et al. Human inhibin genes. Genomic characterisation and sequencing.