Alpha-internexin Antibodies

Alpha-internexin (INA)

Class-IV neuronal intermediate filament that's able to self-assemble. It is involved in the morphogenesis of neurons.

It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. .

Gene Information

Human
Gene Name:	INA
Uniprot:	Q16352
Entrez:	9118

Family

Belongs to:
intermediate filament family

Alternative Names

66 kDa neurofilament protein; alphaInternexin; alpha-Internexin; alpha-Inx; FLJ18662; FLJ57501; INA; internexin neuronal intermediate filament protein, alpha; MGC12702; NEF5; neurofilament 5 (66kD); Neurofilament 5; Neurofilament-66; neurofilament-66, tax-binding protein; NF-66; NF-66alpha-internexin; TXBP-1

Molecular Weight

Mass (kDA):
55.391 kDA

Genomic Context

Human
Location:	10q24.33
Sequence:	10; NC_000010.11 (103277138..103290346)

Tissue Specificity

Found predominantly in adult CNS.

Diseases

• Neoplasms
• Pain
• Malignant Neoplasms
• Plant Diseases
• Oligodendroglioma
• Glioma
• Hiv Infections
• Obesity
• Malnutrition
• Brain Neoplasms
• Astrocytoma
• Infective Disorder

• Dermatitis, Phototoxic
• Systemic Infection
• Glioblastoma
• Myocardial Infarction
• Ischemia
• Cardiac Arrhythmia
• Influenza

Pathways

• Systemic Acquired Resistance
• Disease Resistance
• Pathogenesis
• Cell Death
• Regeneration
• Localization
• Membrane Fusion
• Excretion
• Secretion
• Cold Acclimation
• Transport
• Complement Activation
• Phagocytosis

• Fibrinolysis
• Mitosis
• Methylation
• Transposition
• Mitochondrial Depolarization
• Cognition
• Interphase

PTMs

• Cleavage
• Phosphorylation
• Glycosylation

• Methylation
• Oxidation
• Acetylation

• Iodination

Research Areas

• Cancer
• Cell Biology
• Cellular Markers
• Neuronal Cell Markers
• Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/INA

Discover The Best Uses Of The INA Marker

If you've chosen to use a monoclonal antibodies against anti-AMP Deaminase, isoform E (AMPD3), you are about to learn the benefits of Boster Bio's INA Marker. This tool allows scientists to perform targeted tests for species or applications as well as specific samples. With this tool you'll be able get credits for the product. It's also beneficial to scientists from all over the world.

Boster Bio Anti-AMP Deaminase, Isoform E (AMPD3) Monoclonal Antibody

Antibodies against Adenosine Monophosphate deaminase (AMPD3) are highly efficient in finding AMPD3 protein in cells. Its 90 kDa size and 767 amino acids make it a highly regulated enzyme. It is an intermediate point of the Adenylate Catabolic Pathway.

AMPD3 is an Oligomeric enzyme that catalyzes hydrolytic deamination of adenylic acid into inosine monophosphate. AMPDs regulate the purine nucleotide pool within several types of animal tissues. They play a significant function in purine nucleotide cycle and carbohydrate metabolism in human cells. Although the majority of AMPD3 mutations in humans do not cause symptoms they are able to use it to prolong their lives.

Research has demonstrated that cyclic AMP plays a key role in the regulation of sporulation Saccharomyces cerevisiae yeast. Fasting activates the pathway cAMP/PKA which results in increased levels of cAMP in cells. Furthermore, anti-AMPD3 antibody are particularly effective in inhibiting the production of ascospores in the microbial cell differentiation process.

Researchers have discovered that Boster Bio Anti AMP Deaminotransferase E monoclonal antibody is able to detect cAMP dependent protein kinase. These antibodies are directed at PKA and PKG which convert cAMP to cGMP.

The cAMP-receptor proteins are located in various cells in different compartments. It inhibits the expression of antimicrobial peptides , and hinders the synthesis of cyclic AMP. It also blocks the production of cathelicidin-mRNA. However, it doesn't alter the innate immunity of the placenta.

Boster Bio Anti-CD86 Antibody Picoband(tm)

The Boster Bio Anti-CD86 Antibody has a high-quality monoclonal antibody to detect of CD86 in human cells. Its catalytic function is based on human CD86 protein. The CD86 gene codes a type I membrane protein, known as Cluster of Differentiation86. It is located on the human chromosome 23q21. Its price is based on the length of the immunogen and the length of the antibody.

The anti-CD86 antibody of Boster Bio has been tested on several platforms that include ELISA and Flow Cytometry. It is validated on human mouse, rat, and human cell samples. Unlike other antibodies, it is able to identify several protein variants and identify both negative and positive samples in a single blot. Its accuracy is high and it is built upon multiple validation methods which include WB, IHC, and Immunofluorescence.

Boster Bio Anti-AMPD3

Despite the fact that AMPD3 has been identified as a target of hsa–miR-181a-3p, the gene is still to be discovered in a living person. This is due to the fact that the gene isn't recognized in a variety of species. The best way to identify AMPD3 would be to analyze the sequence of its target. However, hsa–miR-181a-3p has demonstrated to regulate the expression of many genes including CDh23 as well as COL11A1, HISPPD1, ATP11C and AASS.

Boster Research Corporation invented this antibody. It interacts with human cells as well as particles, and is not hazardous. The boster Bio Anti-AMPD3 is approved for use in immunofluorescence, WB, and ELISA. It has been widely used in cancer research and can be applied to researchers all over the world. If you aren't sure whether it is right for you, you can request an evaluation.

Boster Bio Anti-CD86 Antibody

Boster Bio Anti CD86 Antibody is a potent tool for measuring the highest levels of CD86 expression in cell culture and research. Researchers can detect high levels of expression in their experiments by using the antibody on both positive and negative samples. In turn, this antibody aids researchers in understanding how the immune system functions and how cells react in different environments.

The Boster Bio Anti-CD86 Antibody was designed to recognize CD86 on human cells. Scientists can easily conduct multiple experiments using the same antibody due to its unique design. Picokine(tm) is a unique immunogen platform, is a platform for high-sensitivity ELISA. It increases the sensitivity to the level of a picogram. The Picokine(tm) ELISA kits are validated for IHC, WB, and Flow. Its exclusive Picoband technology is based on knowledge of the design of immunogens, as well as technical support from BeNeLux distributor Sanbio.