IL7R Antibodies

Interleukin-7 receptor subunit alpha (IL7R)

Receptor for interleukin-7.

Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

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Gene Information

Human
Gene Name:	IL7R
Uniprot:	P16871
Entrez:	3575

Family

Belongs to:
type I cytokine receptor family

Alternative Names

CD127 antigen; CD127; CD127ILRA; CDW127; IL-7 R alpha; IL-7 receptor subunit alpha; IL7R alpha; IL-7R alpha; IL-7R subunit alpha; IL7R; IL7RA; IL-7Ra; IL-7R-alpha; interleukin 7 receptor alpha chain; interleukin 7 receptor isoform H5-6; interleukin 7 receptor; interleukin-7 receptor subunit alpha

Molecular Weight

Mass (kDA):
51.579 kDA

Genomic Context

Human
Location:	5p13.2
Sequence:	5; NC_000005.10 (35856891..35879603)

Subcellular Localizations

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted.

Diseases

• Sclerosis
• Multiple Sclerosis
• Leukemia
• Autoimmune Reaction
• Acute Lymphocytic Leukemia
• Immunologic Deficiency Syndromes
• Severe Combined Immunodeficiency
• Inflammation
• Nervousness
• Malignant Neoplasms
• Neoplasms
• Congenital Combined Immunodeficiency
• Hyperplasia

• Autoimmune Diseases
• Autoimmunity
• Precursor T-cell Lymphoblastic Leukemia-lymphoma
• Sarcoidosis
• Lymphoma
• Cns Disorder
• Primary Biliary Cirrhosis

Interacting Proteins

• IL7

Pathways

• Pathogenesis
• Cell Development
• Immune Response
• Cell Differentiation
• Cell Proliferation
• T Cell Homeostasis
• B Cell Differentiation
• Cell Activation
• Hypersensitivity
• Cell Cycle
• Segmentation
• Cell Adhesion
• Jak-stat Cascade

• Lymph Node Development
• T Cell Activation
• Aging
• V(d)j Recombination
• Cell Division
• Mrna Splicing
• T Cell Proliferation

PTMs

• Phosphorylation

• Cleavage

Research Areas

• Apoptosis
• Cytokine Research
• Immunology
• Innate Immunity
• Phospho-Specific

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IL7R

Best Uses Of The IL7R Marker

You've probably heard about the marker IL7R. What are its most effective uses and advantages? This article will provide more about the IL7R alpha chain and IL2RA gamma chain, and offer some tips to help you use these markers more efficiently. This article also introduces the Anti-IL2RA antibody. This antibody is employed in many scientific applications.

Marker IL7R

The IL7R gene contains instructions for the interleukin 7 alpha chain that is a component of the IL-7 or TSLP receptors. The interleukin 7 receptor can be located in B and T cells, but also in several different types of immune cells, including monocytes and dendritic cells. This marker is used by researchers to determine if it is present in different types of organs and tissues.

The IL-7R/IL7R pathway is linked to a subset of T-cell lymphoma. The IL-7R/IL-7R pathway is required to maintain the optimal level of the protein. Insufficient levels can negatively impact the development of T cells and interfere with the homeostasis of T cells. The excess levels can trigger the proliferation of T cells.

IL7R-alpha chain

The Anti-IL7R alpha chain in Bostern Bio reacts with human and rats IL7R. The Boster Bio Anti-IL7R Alpha chain can be stored at -20°C for one year or frozen for six months. This reagent is accompanied by 5mg BSA. Blocking peptides can be purchased separately if required.

In transgenic zebrafish, the IL7R alpha-chain was expressed using an mCherry, eGFP, and Myc DNA construct. The PCR amplification as well as the gateway cloning of the human IL7R Open-Reading Frame and a gateway cloning into an rag2-promoter-based vector produced the IL7R alpha chain. The IL7R gene is an oncogene, affecting the proliferation and survival of lymphoid precursor cells.

In vivo, the transcription of IL7Ra is inhibited by IL8 and IL7 signaling. Naive T cells must compete with each other to receive IL-7-mediated survival signals that are available in only very few. Inhibition of IL7Ra transcription by IL-7 is seen in T cells that are not naive, which results in lower IL7Ra levels on T cells with CD4+.

Experiments have proven that IL7Ra is expressed by peripheral T cells, while IL4Ra is not. Experiments conducted using fresh LNT in culture demonstrated that IL7Ra expression decreased when T cells were removed in vivo. In vivo cytokines might be involved in promoting IL7Ra. The antagonists of IL7Ra could be a novel treatment for MS.

The expression of IL7R in donor T cells was similar in both IL-7-replete and IL-7-deficient mice. In hosts with IL-7 deficiency B6 LNT expressed 2.5-fold more surface IL7Ra in IL-7+ hosts than B6LNT from hosts with IL-7+. These data support the hypothesis that endogenous IL-7 inhibits the expression of IL-7R on donor T cells.

IL2RA gamma chain

The cytokine IL2RA Gamma chains are found in the human body. The gamma chain is located on red blood cells. A matching antibody pair is utilized in ELISA to measure amount of target bound. Pre-coated target-specific antibodies can be placed on plates that have 96 wells. The samples are then added to the wells and a biotinylated monoclonal detection antibody (from goat) is added. The reaction takes place in the presence of enzyme-antibody-target complex. The amount of target in the original specimen determines the intensity of the signal.

This IL2RA gamma-chain antibody reacts with Human. It is available from Boster Bio (catalog no PA1747). The antibody is a blocking protein that can be stored at -20degC for up to six month. It contains 0.05mg of NaN3 and 5mg BSA. To increase the amount, you can purchase an extract of the IL2RA gamma chain peptide.

Human IL2RA Gamma chain mutations cause in severe combined immunodeficiency (SCID). This condition can cause life-threatening infectionsand can be treated with gene therapy or bone marrow transplantation. The condition could lead to long-term complications. Additionally certain patients develop severe cutaneous HPV infection and no immune reconstitution will be able to tell whether they will relapse. The IL2RA gamma chain mutations were observed in SCID patients who had alterations to gc. Additionally, HPV susceptibility is only present in patients with SCID with gc mutations.

The IL-15/IL-15Ra receptor is not fully understood in the cell membrane. But elegant imaging studies have shown that it is surrounded by numerous cis associations. TCR recruitment is not possible without the IL-15/IL-15Ra-mediated complex and STAT5 is able to be recruited by gc signaling. gc is therefore the key to the IL-15Ra signaling.

Anti-IL2RA antibody

The Anti-IL2RA antibody from BosterBio has been proven effective in Western Blot and Immunohistochemistry. It reacts to Human and Rabbit and was created with IL2RA as the antigen. It can be utilized in many types of immunohistochemistry and ELISA applications. For more information, contact Sanbio. You can also purchase the blocking peptide , or an entire set.

Boster Bio's anti-IL2RA antibodies are extremely sensitive and specific. Boster Bio's antibodies are validated on multiple platforms using positive and negative samples to ensure high specificity and a high affinity. Boster Bio is proud of the fact that they have acknowledged the first reviewers of their products. All scientists across the globe are rewarded with product credits for reviewing their products. In the process, they also have an international database that contains more than 29,000 publications citing their products.

T-ALL

The Boster Bio Anti-IL7R Marker is a rabbit polyclonal antigen that reacts with human IL7R. It should be kept at -20C and frozen for up-to six months. It is made up of 5 mg BSA and 0.05mg NA3. This product should be used as blocking agent. It is a receptive agent for human IL7R. This product can be used to monitor IL7R levels in various cell and tissue kinds.

In a recent study, IL-7R pathway mutations were found to be abundant in patients suffering from early T-cell precursor ALL (ETP-ALL). The authors discovered that this gene was enriched in a subgroup of TAL-LMO-ALL. The results also indicated that the marker could be used to predict T-cell proliferation. However, there are a few questions that remain unanswered.

The IL-7/IL7R signaling pathway is involved in a variety of kinds of cancer. These studies have been restricted to in vitro or association studies. However they have found that there is a connection between IL-7R/cancer. The most striking example is the finding that T-ALL has tumorigenic capacity the IL-7/IL7R. The IL-7/IL7R Marker plays a role in the development of a variety diseases, such as Alzheimer's and STaio istf 5 mg BSA o isissuePplare on'>